Figure 2

A/J and BALB are susceptible to pulmonary inflammation and hyperpermeability in response to sub-chronic V ₂ O ₅ . A/J, BALB, and B6 mice were exposed to 4 weekly doses of V₂O₅ (4 mg/kg) by aspiration and sacrificed 0.25, 1, 3, 6, 21 days after the last exposure. A.) Bronchoalveolar lavage (BALF) protein (μg/mL) and B.) total cells, C.) macrophages, D.) PMNs, and (E) lymphocytes per mL of BALF. Data represent the mean ± SEM (n = 5-15 animals/group). *, significantly different than strain-matched PBS controls. †, significantly different than time-matched B6 mice. δ, significantly different than time-matched BALB mice (P < 0.05).