| Â |
Corn Oil (Control)
|
MCA-treated
|
|---|
Strain
|
PBS
|
V
2
O
5
|
PBS
|
V
2
O
5
|
A/J | 0.0 ± 0.0 | 0.50 ± 0.50 | 3.3 ± 0.75# (0.72 ± 0.036)# | 10 ± 1.4*# (0.72 ± 0.032)# |
BALB | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.78 ± 0.28 (0.49 ± 0.039) | 2.2 ± 0.36* (0.63 ± 0.068) |
- a A/J, BALB, and B6 mice were treated with or without the initiator MCA (10 μg/g), followed by sub-chronic administration of V2O5 (4 mg/kg) or PBS.
- b Number of mice per treatment group: A/J, Oil/PBS and Oil/V2O5 (n = 3), MCA/PBS (n = 4), MCA/V2O5 (n = 15); BALB, Oil/PBS and Oil/V2O5 (n = 3-5), MCA/PBS (n = 8), MCA/V2O5 (n = 13); B6, Oil/PBS and Oil/V2O5 (n = 3-8), MCA/PBS (n = 7), MCA/V2O5 (n = 12).
- c No tumors were detected in B6 mice in any of the experimental groups examined (data not shown).
- d A significant strain effect was detected for tumor size (mm) between A/J (0.72 ± 0.012) and BALB mice (0.59 ± 0.054) (P < 0.05).
- * Significantly different from strain-matched MCA-treated/PBS controls (P < 0.05).
- # Significantly different than treatment-matched BALB mice (A/J vs BALB, P < 0.05).
