Figure 1

Measurement of airway function following exposure to CGUFP. Neonatal rats (7 d of age) were exposed to CGUFP for 20 m/d for 7 d and pulmonary function was assayed 24 hr after the final exposure. Significant increases in lung resistance (A) in response to MeCh challenge and decreases in compliance (B) among DCB230 exposed neonates compared with control groups (air and DCB50). Quasi-static inflation/deflation curves (i.e. pressure-volume loops) (C) and the area within the curves representative of hysteresis (D). Data are means ± SEM and is representative of three independent experiments with 6 animals/group. *p < 0.05, **p < 0.01, ***p < 0.001.