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Table 4 Summary of results from experiments to determine durability, and acute and 7 d inflammatory responses in vivo, for CNT samples and controls

From: Durability and inflammogenic impact of carbon nanotubes compared with asbestos fibres

  

Fibre Changes

Acute Inflammatory Response (24 h)

7 d Inflammatory Response

  

Loss of Mass

Fibre Shortening

Total Cell

PMN Infiltration

Total Protein

IL-6

LDH

Total Cell

PMN Infiltration

Total Protein

IL-6

LDH

Granuloma Response

X607

0 week

N/A

N/A

-

-

-

-

-

-

-

-

-

-

-

 

10 week

+

+

-

-

-

-

-

-

-

-

-

-

-

LFA

0 week

N/A

N/A

+

+

-

-

-

-

-

-

-

-

Yes (ns)

 

10 week

+

-

+

+

-

-

-

-

-

-

-

-

Yes (ns)

LFC

0 week

N/A

N/A

+

+

+

-

-

-

-

-

-

-

Yes (ns)

 

10 week

+

+

-

-

-

-

-

-

-

-

-

-

-

CNT SW

0 week

N/A

N/A

-

-

-

-

-

-

-

-

-

-

-

 

10 week

-

-

-

-

-

-

-

-

-

-

-

-

-

CNT LONG1

0 week

N/A

N/A

+

+

+

+

-

-

-

+

+

+

Yes (s)

 

10 week

+*

+

-

-

-

-

-

-

-

-

-

-

-

  1. This table compiles and summarises data presented in Tables 2 and 3, and Figures 1, 2, 3 and 5. A cross indicates a statistically significant difference between treatment and control (for fibre changes, 10 weeks compared with 0 weeks; for inflammatory responses, response to fibre sample compared with vehicle only). A dash indicates no statistically significant difference.
  2. (+ = statistically significant (p < 0.05); - = not statistically significant; (ns) = not significant; (s) = significant; N/A: not applicable)
  3. * Note: The mass loss for CNTLONG1 10 weeks was just under statistical significance; however the mass losses at 3 weeks, 6 weeks and 24 weeks were significant, and therefore representative statistical significance has been attributed to the 10 week sample here.