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Table 10 Histopathologic observations for male rats.

From: Subchronic inhalation toxicity of gold nanoparticles

GROUP: Control Low Middle High
Number of Animals 8 10 10 8
      N % N % N % N %
  No microscopic findings 8/8 100 10/10 100 6/10 60 5/8 62.5
  Abnormality* 0/8 0 0/10 0 4/10 40 3/8 37.5
Liver   Inflammation Focal minimum 0/8 0 0/10 0 0/10 0 1/8 12.5
  Sign   Multifocal minimum 0/8 0 0/10 0 3/10 30 0/8 0
   Necrosis Focal minimum 0/8 0 0/10 0 0/10 0 2/8 25
   Vacuolation Hepatocellular minimum 0/8 0 0/10 0 1/10 10 1/8 12.5
  No microscopic findings 7/8 87.5 10/10 100 10/10 100 5/8 62.5
Lungs Abnormality* 1/8 12.5 0/10 0 0/10 0 3/8 37.5
  Sign Inflammation* Focal minimum 1/8 12.5 0/10 0 0/10 0 3/8 37.5
   Osseous Metaplasia 0/8 0 0/10 0 0/10 0 1/8 12.5
  1. *, p < 0.05 compared with controls. Abnormality" refers to such changes as inflammation, vacuolization and necrosis upon histopathological examination. One abnormality is counted even if inflammation and necrosis are present simultaneously.