|
GROUP:
|
Control
|
Low
|
Middle
|
High
|
|---|
|
Number of Animals
|
8
|
10
|
10
|
8
|
| | | | | |
N
|
%
|
N
|
%
|
N
|
%
|
N
|
%
|
| |
No microscopic findings
|
8/8
|
100
|
10/10
|
100
|
6/10
|
60
|
5/8
|
62.5
|
| |
Abnormality*
|
0/8
|
0
|
0/10
|
0
|
4/10
|
40
|
3/8
|
37.5
|
|
Liver
| |
Inflammation
|
Focal
|
minimum
|
0/8
|
0
|
0/10
|
0
|
0/10
|
0
|
1/8
|
12.5
|
| |
Sign
| |
Multifocal
|
minimum
|
0/8
|
0
|
0/10
|
0
|
3/10
|
30
|
0/8
|
0
|
| | |
Necrosis
|
Focal
|
minimum
|
0/8
|
0
|
0/10
|
0
|
0/10
|
0
|
2/8
|
25
|
| | |
Vacuolation
|
Hepatocellular
|
minimum
|
0/8
|
0
|
0/10
|
0
|
1/10
|
10
|
1/8
|
12.5
|
| |
No microscopic findings
|
7/8
|
87.5
|
10/10
|
100
|
10/10
|
100
|
5/8
|
62.5
|
|
Lungs
|
Abnormality*
|
1/8
|
12.5
|
0/10
|
0
|
0/10
|
0
|
3/8
|
37.5
|
| |
Sign
|
Inflammation*
|
Focal
|
minimum
|
1/8
|
12.5
|
0/10
|
0
|
0/10
|
0
|
3/8
|
37.5
|
| | |
Osseous Metaplasia
|
0/8
|
0
|
0/10
|
0
|
0/10
|
0
|
1/8
|
12.5
|
- *, p < 0.05 compared with controls. Abnormality" refers to such changes as inflammation, vacuolization and necrosis upon histopathological examination. One abnormality is counted even if inflammation and necrosis are present simultaneously.
