Subchronic inhalation toxicity of gold nanoparticles

Table 10 Histopathologic observations for male rats.

GROUP:					Control		Low		Middle		High
Number of Animals					8		10		10		8
					N	%	N	%	N	%	N	%
	No microscopic findings				8/8	100	10/10	100	6/10	60	5/8	62.5
	Abnormality*				0/8	0	0/10	0	4/10	40	3/8	37.5
Liver		Inflammation	Focal	minimum	0/8	0	0/10	0	0/10	0	1/8	12.5
	Sign		Multifocal	minimum	0/8	0	0/10	0	3/10	30	0/8	0
		Necrosis	Focal	minimum	0/8	0	0/10	0	0/10	0	2/8	25
		Vacuolation	Hepatocellular	minimum	0/8	0	0/10	0	1/10	10	1/8	12.5
	No microscopic findings				7/8	87.5	10/10	100	10/10	100	5/8	62.5
Lungs	Abnormality*				1/8	12.5	0/10	0	0/10	0	3/8	37.5
	Sign	Inflammation*	Focal	minimum	1/8	12.5	0/10	0	0/10	0	3/8	37.5
		Osseous Metaplasia			0/8	0	0/10	0	0/10	0	1/8	12.5

*, p < 0.05 compared with controls. Abnormality" refers to such changes as inflammation, vacuolization and necrosis upon histopathological examination. One abnormality is counted even if inflammation and necrosis are present simultaneously.

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