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Figure 6 | Particle and Fibre Toxicology

Figure 6

From: Darkfield-Confocal Microscopy detection of nanoscale particle internalization by human lung cells

Figure 6

Statistical analysis of mean particle location in cells exposed to 27 nm TiO 2 for varying lengths of time. Particle localization within the z-axis was taken as the optical section containing maximal intensity in the dark field channel, and is plotted relative to the section in which DAPI fluorescence was most intense (center of nucleus normalized to zero, depicted as horizontal blue bar). Within each group of particles, the black line illustrates an averaged (mean) particle location for the center of each particle, as detected using DF-CLSM. Note that at 120 min incubation the particles are located above, below and at the midpoint of the nucleus, suggesting variations in cell morphology and distinct transit paths.

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