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Table 1 Sensitivity of Interstitial Fibrotic Response to SWCNTs versus MWCNTs

From: Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

  SWCNTs1 MWCNTs
Aspiration Dose
(ug)
10 ug 80 ug
Lung Burden Distribution
(%)
10% Alveolar Macrophage
90% Interstitial
70% Alveolar Macrophage
8% Interstitial
20% Airspace Granuloma
2% Subpleural Tissue
Alveolar Interstitial Dose
(ug)
9 ug 6.4 ug
Connective Tissue Thickness (um) 0.10 to 1.10
Control Exposed
0.11 to 0.19
Control Exposed
Sensitivity
Δum Thickness/Δug Dose
0.11 um/ug 0.013 um/ug
  1. 1 Data for dispersed SWCNT interstitial response from Mercer et al. [3]