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Table 2 Promoter CpG site DNA methylation of four tumor suppressor genes measured in post-exposure and baseline samples

From: Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study

CpG site N DNA methylation
   Baseline sample Post-exposure sample p-value
APC (%5 mC)       
    site 1 60 5.77 (5.41; 6.13) 6.13 (5.77; 6.49) 0.06
    site 2 60 5.39 (5.10; 5.68) 5.45 (5.16; 5.74) 0.72
    site 3 60 3.63 (3.32; 3.93) 3.92 (3.62; 4.23) 0.11
    site 4 60 3.86 (3.56; 4.15) 4.06 (3.77; 4.35) 0.25
    All sites combined 60 4.65 (3.70; 5.61) 4.89 (3.94; 5.85) 0.005
p16 (%5 mC)       
    site 1 61 2.02 (1.81; 2.22) 2.34 (2.13; 2.55) 0.012
    site 2 61 2.75 (2.51; 2.98) 2.9 (2.66; 3.14) 0.20
    site 3 61 1.66 (1.43; 1.89) 1.88 (1.65; 2.11) 0.11
    site 4 61 2.21 (2.05; 2.36) 2.17 (2.01; 2.33) 0.70
    Site5 61 1.84 (1.57; 2.12) 1.93 (1.65; 2.20) 0.60
    Site 6 61 1.71 (1.49; 1.92) 1.78 (1.56; 2.00) 0.58
    Site 7 61 3.11 (2.83; 3.40) 3.31 (3.03; 3.60) 0.15
    All sites combined 61 2.2 (1.78; 2.62) 2.34 (1.92; 2.76) 0.006
p53 (%5 mC)       
    site 1 58 3.02 (2.83; 3.22) 2.93 (2.73; 3.13) 0.16
    site 2 58 11.88 (11.26; 12.50) 11.56 (10.94; 12.18) 0.13
    site 3 58 3.57 (3.37; 3.78) 3.56 (3.35; 3.76) 0.85
    site 4 58 6.96 (6.52; 7.41) 6.59 (6.14; 7.03) 0.006
    All sites combined 58 6.36 (2.93; 9.79) 6.16 (2.73; 9.60) 0.015
RASSF1A (%5 mC)       
    site 1 57 3.68 (3.23; 4.13) 3.14 (2.69; 3.59) 0.003
    site 2 57 10.14 (9.01; 11.27) 8.59 (7.45; 9.72) < 0.001
    site 3 57 8.43 (7.16; 9.70) 7.21 (5.94; 8.49) 0.009
    site 4 57 10.61 (9.34; 11.88) 9.22 (7.95; 10.49) 0.002
    All sites combined 57 8.17 (5.44; 10.90) 7.08 (4.36; 9.81) < 0.001