From: Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
CpG site | N | DNA methylation | ||||
---|---|---|---|---|---|---|
 |  | Baseline sample | Post-exposure sample | p-value | ||
APC (%5 mC) | Â | Â | Â | Â | Â | Â |
    site 1 | 60 | 5.77 | (5.41; 6.13) | 6.13 | (5.77; 6.49) | 0.06 |
    site 2 | 60 | 5.39 | (5.10; 5.68) | 5.45 | (5.16; 5.74) | 0.72 |
    site 3 | 60 | 3.63 | (3.32; 3.93) | 3.92 | (3.62; 4.23) | 0.11 |
    site 4 | 60 | 3.86 | (3.56; 4.15) | 4.06 | (3.77; 4.35) | 0.25 |
    All sites combined | 60 | 4.65 | (3.70; 5.61) | 4.89 | (3.94; 5.85) | 0.005 |
p16 (%5 mC) | Â | Â | Â | Â | Â | Â |
    site 1 | 61 | 2.02 | (1.81; 2.22) | 2.34 | (2.13; 2.55) | 0.012 |
    site 2 | 61 | 2.75 | (2.51; 2.98) | 2.9 | (2.66; 3.14) | 0.20 |
    site 3 | 61 | 1.66 | (1.43; 1.89) | 1.88 | (1.65; 2.11) | 0.11 |
    site 4 | 61 | 2.21 | (2.05; 2.36) | 2.17 | (2.01; 2.33) | 0.70 |
    Site5 | 61 | 1.84 | (1.57; 2.12) | 1.93 | (1.65; 2.20) | 0.60 |
    Site 6 | 61 | 1.71 | (1.49; 1.92) | 1.78 | (1.56; 2.00) | 0.58 |
    Site 7 | 61 | 3.11 | (2.83; 3.40) | 3.31 | (3.03; 3.60) | 0.15 |
    All sites combined | 61 | 2.2 | (1.78; 2.62) | 2.34 | (1.92; 2.76) | 0.006 |
p53 (%5 mC) | Â | Â | Â | Â | Â | Â |
    site 1 | 58 | 3.02 | (2.83; 3.22) | 2.93 | (2.73; 3.13) | 0.16 |
    site 2 | 58 | 11.88 | (11.26; 12.50) | 11.56 | (10.94; 12.18) | 0.13 |
    site 3 | 58 | 3.57 | (3.37; 3.78) | 3.56 | (3.35; 3.76) | 0.85 |
    site 4 | 58 | 6.96 | (6.52; 7.41) | 6.59 | (6.14; 7.03) | 0.006 |
    All sites combined | 58 | 6.36 | (2.93; 9.79) | 6.16 | (2.73; 9.60) | 0.015 |
RASSF1A (%5 mC) | Â | Â | Â | Â | Â | Â |
    site 1 | 57 | 3.68 | (3.23; 4.13) | 3.14 | (2.69; 3.59) | 0.003 |
    site 2 | 57 | 10.14 | (9.01; 11.27) | 8.59 | (7.45; 9.72) | < 0.001 |
    site 3 | 57 | 8.43 | (7.16; 9.70) | 7.21 | (5.94; 8.49) | 0.009 |
    site 4 | 57 | 10.61 | (9.34; 11.88) | 9.22 | (7.95; 10.49) | 0.002 |
    All sites combined | 57 | 8.17 | (5.44; 10.90) | 7.08 | (4.36; 9.81) | < 0.001 |