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Table 2 Promoter CpG site DNA methylation of four tumor suppressor genes measured in post-exposure and baseline samples

From: Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study

CpG site

N

DNA methylation

  

Baseline sample

Post-exposure sample

p-value

APC (%5 mC)

      

    site 1

60

5.77

(5.41; 6.13)

6.13

(5.77; 6.49)

0.06

    site 2

60

5.39

(5.10; 5.68)

5.45

(5.16; 5.74)

0.72

    site 3

60

3.63

(3.32; 3.93)

3.92

(3.62; 4.23)

0.11

    site 4

60

3.86

(3.56; 4.15)

4.06

(3.77; 4.35)

0.25

    All sites combined

60

4.65

(3.70; 5.61)

4.89

(3.94; 5.85)

0.005

p16 (%5 mC)

      

    site 1

61

2.02

(1.81; 2.22)

2.34

(2.13; 2.55)

0.012

    site 2

61

2.75

(2.51; 2.98)

2.9

(2.66; 3.14)

0.20

    site 3

61

1.66

(1.43; 1.89)

1.88

(1.65; 2.11)

0.11

    site 4

61

2.21

(2.05; 2.36)

2.17

(2.01; 2.33)

0.70

    Site5

61

1.84

(1.57; 2.12)

1.93

(1.65; 2.20)

0.60

    Site 6

61

1.71

(1.49; 1.92)

1.78

(1.56; 2.00)

0.58

    Site 7

61

3.11

(2.83; 3.40)

3.31

(3.03; 3.60)

0.15

    All sites combined

61

2.2

(1.78; 2.62)

2.34

(1.92; 2.76)

0.006

p53 (%5 mC)

      

    site 1

58

3.02

(2.83; 3.22)

2.93

(2.73; 3.13)

0.16

    site 2

58

11.88

(11.26; 12.50)

11.56

(10.94; 12.18)

0.13

    site 3

58

3.57

(3.37; 3.78)

3.56

(3.35; 3.76)

0.85

    site 4

58

6.96

(6.52; 7.41)

6.59

(6.14; 7.03)

0.006

    All sites combined

58

6.36

(2.93; 9.79)

6.16

(2.73; 9.60)

0.015

RASSF1A (%5 mC)

      

    site 1

57

3.68

(3.23; 4.13)

3.14

(2.69; 3.59)

0.003

    site 2

57

10.14

(9.01; 11.27)

8.59

(7.45; 9.72)

< 0.001

    site 3

57

8.43

(7.16; 9.70)

7.21

(5.94; 8.49)

0.009

    site 4

57

10.61

(9.34; 11.88)

9.22

(7.95; 10.49)

0.002

    All sites combined

57

8.17

(5.44; 10.90)

7.08

(4.36; 9.81)

< 0.001