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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Figure 4

Representative gross lesion and histology of lungs after instillation of ZnONP at 150 cm2 /rat. (A), lungs were contracted and collapsed by ZnONP treatment and this caused puckering of the lung surface. (B - E), each figure is composed of a low power view (left, 25×), high power view of bronchiolar epithelium (middle, 400×), and alveoli (right, 400×). (B) vehicle control at 24 h; (C) ZnONP at 24 h; (D) ZnONP at 1 wk; (E) ZnONP at 4 wks. Red arrows indicate eosinophils and arrowheads indicate foamy macrophages. Black arrows indicate goblet cells.

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