Figure 2

Markers for Alveolar Macrophages. BAL cytokine concentrations of galectin-3 (A) and osteopontin (SPP1) (B) in female PPARγ wild-type (wt/wt) (white bars) and PPARγ mutant mice (P465L/wt) (grey bars) - markers mainly derived from alveolar macrophages and known to be associated with carbon-nanoparticle-induced pulmonary inflammation. HCC: untreated home cage controls; SHAM-24 h: water-instilled animals at 24 h time point; CNP-24 h: particle-instilled mice at 24 h time point; CNP-72 h: particle-instilled mice at 72 h time point. For sample size, please see Table1. Statistics: General Linear Model (GLM): Galectin-3: genotype: F/W = 8.194, df = 1, **P = 0.006; treatment: F/W = 6.095, df = 3,**P = 0.001; SPP1: genotype: F/W = 19.786, df = 1, ***P < 0.001; treatment: F/W = 15.921, df = 3, ***P < 0.001;