Figure 3

Markers for Epithelial Cells. BAL cytokine concentrations of CXCL5 (A), and lipocalin-2 (B) in female PPARγ wild-type (wt/wt) (white bars) and PPARγ mutant mice (P465L/wt) (grey bars) - markers mainly derived from lung epithelium, and known to be associated with carbon-nanoparticle-induced pulmonary inflammation. HCC: untreated home cage controls; SHAM-24 h: water-instilled animals at 24 h time point; CNP-24 h: particle-instilled mice at 24 h time point; CNP-72 h: particle-instilled mice at 72 h time point. For sample size, please see Table1. Statistics: General Linear Model (GLM): CXCL5: genotype: F/W = 0.205, df = 1, **P = 0.6524; treatment: F/W = 5.334, df = 3, **P = 0.003; lipocalin-2: genotype: F/W = 0.007, df = 1, P < 0.9348; treatment: F/W = 56.810, df = 3, ***P < 0.001;