Skip to main content


Figure 5 | Particle and Fibre Toxicology

Figure 5

From: Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms

Figure 5

ROS generation by NR8383 cells after particle treatment. (A) Intracellular ROS were measured via fluorescence of DCFH-DA after particle treatment of 40 μg/cm2. (B) EPR measurements in NR8383 supernatant using the spintrap DMPO show a concentration-dependent generation of ROS induced by treatment with both TiO2 and DQ12 particles. In both experiments AM were treated for 3 h. Figures represent mean ± SEM of four independent experiments, with * p < 0.05 and ** p < 0.01 vs. untreated control (ANOVA with LSD post-hoc comparison) in Figure B.

Back to article page