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Table 3 Excess vasocontraction (in %) induced by N'-monomethyl L-arginine (L-NMMA, 0.10 mM) after PGF precontraction (1 μM) in aorta segments from ApoE-/- mice after intratracheal instillation of TiO2 particles or control solution (90% saline and 10% BAL fluid).

From: Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2

Exposure i.t. instillation Drug - tempol + tempol
Control L-NMMA 17.0 ± 2.84 11.3 ± 1.08
fTiO2   10.2 ± 1.49 14.3 ± 2.62
pTiO2   14.4 ± 2.89 13.2 ± 2.21
nTiO2   12.4 ± 1.65 15.9 ± 3.67
  1. The measurements were done in both absence and ex vivo presence of the SOD mimic, tempol. Data are expressed as means ± SEM (n = 10-11).