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Table 3 Excess vasocontraction (in %) induced by N'-monomethyl L-arginine (L-NMMA, 0.10 mM) after PGF2α precontraction (1 μM) in aorta segments from ApoE-/- mice after intratracheal instillation of TiO2 particles or control solution (90% saline and 10% BAL fluid).

From: Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2

Exposure i.t. instillation

Drug

- tempol

+ tempol

Control

L-NMMA

17.0 ± 2.84

11.3 ± 1.08

fTiO2

 

10.2 ± 1.49

14.3 ± 2.62

pTiO2

 

14.4 ± 2.89

13.2 ± 2.21

nTiO2

 

12.4 ± 1.65

15.9 ± 3.67

  1. The measurements were done in both absence and ex vivo presence of the SOD mimic, tempol. Data are expressed as means ± SEM (n = 10-11).
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Particle and Fibre Toxicology

ISSN: 1743-8977

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