Skip to main content

Table 4 Inflammatory markers measured in mice having received two intratracheal instillations of either control bronchoalveolar lavage (BAL) suspension or 0.5 mg/(kg bodyweight) of one of the particle suspensions; fTiO2, pTiO2, or nTiO2, separated by 24 hours (n = 10-11).

From: Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2

Exposure i.t. instillation

mRNA expression level (Median (quartile 25-75%))

 

Mcp-1 (*10 -9 )

Mip-2 (*10 -9 )

Icam-1 (*10 -6 )

Vcam-1 (*10 -6 )

Vegf (*10 -6 )

Control

54.5 (27.7-89.3)

84.5 (41.5-150.6)

40.8 (27.4-70.2)

0.62 (0.32-0.88)

96.9 (59.3-271.2)

fTiO2

24.4 (9.9-38.9)

71.9 (35.2-111.6)

32.8 (29.0-54.4)

0.34 (0.19-0.60)

99.7 (74.2-109.4)

pTiO2

37.1 (24.3-52.8)

77.8 (36.2-140.0)

30.3 (25.7-55.2)

0.38 (0.19-1.04)

105.1 (90.3-168.0)

nTiO2

27.3 (20.7-64.9)

49.1 (39.0-237.9)

38.9 (18.3-66.8)

0.36 (0.27-0.63)

80.1 (47.0-144.1)

  1. Expression of mRNA is normalised to 18S rRNA.