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Table 4 Inflammatory markers measured in mice having received two intratracheal instillations of either control bronchoalveolar lavage (BAL) suspension or 0.5 mg/(kg bodyweight) of one of the particle suspensions; fTiO2, pTiO2, or nTiO2, separated by 24 hours (n = 10-11).

From: Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2

Exposure i.t. instillation mRNA expression level (Median (quartile 25-75%))
  Mcp-1 (*10 -9 ) Mip-2 (*10 -9 ) Icam-1 (*10 -6 ) Vcam-1 (*10 -6 ) Vegf (*10 -6 )
Control 54.5 (27.7-89.3) 84.5 (41.5-150.6) 40.8 (27.4-70.2) 0.62 (0.32-0.88) 96.9 (59.3-271.2)
fTiO2 24.4 (9.9-38.9) 71.9 (35.2-111.6) 32.8 (29.0-54.4) 0.34 (0.19-0.60) 99.7 (74.2-109.4)
pTiO2 37.1 (24.3-52.8) 77.8 (36.2-140.0) 30.3 (25.7-55.2) 0.38 (0.19-1.04) 105.1 (90.3-168.0)
nTiO2 27.3 (20.7-64.9) 49.1 (39.0-237.9) 38.9 (18.3-66.8) 0.36 (0.27-0.63) 80.1 (47.0-144.1)
  1. Expression of mRNA is normalised to 18S rRNA.