Skip to main content

Table 4 Hematological parameters of treated mice (Mean ± S.D., n = 10).

From: Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles

Parameters

Saline

Til-HCO-SLN

Blank HCO-SLN

Tilmicosin (n = 5)

WBC (109/L)

H

5.51 ± 1.55

5.52 ± 1.68

4.95 ± 1.39

 
 

L

5.89 ± 1.80

5.05 ± 1.06

5.22 ± 0.93

5.16 ± 0.78

RBC

H

8.56 ± 1.30

7.58 ± 1.40

7.07 ± 1.14b

 

(1012/L)

L

9.64 ± 0.79

9.58 ± 0.96

9.63 ± 0.56

9.08 ± 0.69

HCT (L/L)

H

0.44 ± 0.05

0.40 ± 0.03

0.36 ± 0.05b

 
 

L

0.59 ± 0.09

0.61 ± 0.07

0.58 ± 0.06

0.57 ± 0.07

MCV (fL)

H

51.01 ± 2.69

51.06 ± 2.10

51.72 ± 4.05

 
 

L

60.37 ± 5.74

63.18 ± 4.22

60.63 ± 5.34

62.47 ± 4.76

HGB (g/L)

H

141.44 ± 10.48

129.89 ± 10.25

119.43 ± 15.80b

 
 

L

153.63 ± 9.97

155.00 ± 12.00

153.38 ± 6.02

147.80 ± 4.21

MCH (pg)

H

16.84 ± 2.33

16.44 ± 1.67

16.99 ± 1.77

 
 

L

15.96 ± 0.46

16.21 ± 0.57

15.94 ± 0.54

16.30 ± 0.80

MCHC (g/L)

H

329.33 ± 32.11

320.70 ± 22.14

328.00 ± 19.47

 
 

L

266.88 ± 29.78

257.13 ± 15.75

264.50 ± 23.68

262.40 ± 27.93

PLT (109/L)

H

873.89 ± 139.28

812.29 ± 157.35

802.00 ± 154.55

 
 

L

971.13 ± 145.25

967.63 ± 171.96

925.88 ± 219.88

972.60 ± 233.96

MPV (fL)

H

6.74 ± 1.78

6.50 ± 1.14

6.25 ± 1.16

 
 

L

5.43 ± 0.29

5.28 ± 0.21

5.25 ± 0.22

5.32 ± 0.38

PCT (L/L)

H

0.57 ± 0.21

0.47 ± 0.10

0.40 ± 0.11b

 
 

L

0.53 ± 0.07

0.57 ± 0.09

0.55 ± 0.11

0.56 ± 0.06

RDW (fL)

H

11.83 ± 3.81

11.70 ± 2.28

11.75 ± 1.74

 
 

L

17.21 ± 0.79

18.00 ± 1.90

17.47 ± 2.02

17.72 ± 1.37

NEU (%)

H

14.75 ± 2.02

15.70 ± 2.22

17.83 ± 1.50

 
 

L

15.96 ± 5.04

20.06 ± 5.33

18.99 ± 3.12

20.44 ± 5.95

LYM (%)

H

84.25 ± 2.78

81.64 ± 3.94

80.63 ± 1.32

 
 

L

80.71 ± 5.68

74.93 ± 5.84

76.43 ± 4.69

76.88 ± 6.40

MON (%)

H

0.85 ± 0.07

1.73 ± 1.13

1.30 ± 0.36

 
 

L

2.84 ± 1.03

4.30 ± 1.77

3.85 ± 1.73

2.24 ± 1.18

EOS (%)

H

0.20 ± 0.08

0.23 ± 0.19

0.15 ± 0.10

 
 

L

0.26 ± 0.17

0.40 ± 0.13

0.33 ± 0.10

0.16 ± 0.11

BAS (%)

H

0.17 ± 0.10

0.24 ± 0.14

0.18 ± 0.16

 
 

L

0.23 ± 0.07

0.31 ± 0.22

0.41 ± 0.29

0.28 ± 0.15

  1. a Significant difference between Til-HCO-SLN and saline treated mice, p < 0.05.
  2. b Significant difference between blank HCO-SLN and saline treated mice, p < 0.05.
  3. Abbreviations: H: high dose; L: low dose; WBC: white blood cells; RBC: red blood cells; HCT: haematocrit; MCV: mean corpuscular volume; HGB: hemoglobin; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; PLT: blood platelet; MPV: mean platelet volume; PCT: plateletcrit; RDW: red cell distribution width; NEU: neutrophils; LYM: lymphocytes; MON: monocytes; EOS: eosinophils; BAS: basophils.