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Table 2 Cytokine concentrations in BAL fluid from mice exposed to Ag nanoparticles by inhalation. Data from Ref. 34 for Cu nanoparticle exposure using the same protocol are shown for comparison.

From: Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model

Exposure IL-6 IL-12(p40) TNF-α KC MCP-1 MIP-1α GM-CSF
Group
Silver pg/ml
Controls ND 29.1 ± 2.9 ND ND ND ND ND
Ag 0 wk post exposure ND 64.1 ± 10.6* ND 4.24 ± 0.88* ND ND ND
Ag 3 wks post exposure ND 53.6 ± 21.9 ND 2.96 ± 0.54 ND ND ND
Detection limit 0.67 0.73 44.3 1.77 9.58 27.31 1.48
Copper     pg/ml    
Controls ND 35.0 ± 6.8 21.4 ± 3.3 0.90 ± 0.12 ND ND 0.16 ± 0.08
Cu 0 wk post-exposure 82.8 ± 13.8* 1210 ± 10.1* 161 ± 10.4* 215 ± 17.0* 4400 ± 401* 309 ± 37.2* 70.2 ± 10.9*
Cu 3 wk post-exposure ND 42.7 ± 4.8 17.3 ± 1.6 1.44 ± 0.12 ND ND 0.27 ± 0.13
Detection limit 0.11 0.08 13 0.19 3.44 2.01 0.08
  1. ND Not detectable
  2. * Significantly different from sham-exposed animals (p < 0.05)