Skip to main content

Table 2 Cytokine concentrations in BAL fluid from mice exposed to Ag nanoparticles by inhalation. Data from Ref. 34 for Cu nanoparticle exposure using the same protocol are shown for comparison.

From: Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model

Exposure

IL-6

IL-12(p40)

TNF-α

KC

MCP-1

MIP-1α

GM-CSF

Group

Silver

pg/ml

Controls

ND

29.1 ± 2.9

ND

ND

ND

ND

ND

Ag 0 wk post exposure

ND

64.1 ± 10.6*

ND

4.24 ± 0.88*

ND

ND

ND

Ag 3 wks post exposure

ND

53.6 ± 21.9

ND

2.96 ± 0.54

ND

ND

ND

Detection limit

0.67

0.73

44.3

1.77

9.58

27.31

1.48

Copper

   

pg/ml

   

Controls

ND

35.0 ± 6.8

21.4 ± 3.3

0.90 ± 0.12

ND

ND

0.16 ± 0.08

Cu 0 wk post-exposure

82.8 ± 13.8*

1210 ± 10.1*

161 ± 10.4*

215 ± 17.0*

4400 ± 401*

309 ± 37.2*

70.2 ± 10.9*

Cu 3 wk post-exposure

ND

42.7 ± 4.8

17.3 ± 1.6

1.44 ± 0.12

ND

ND

0.27 ± 0.13

Detection limit

0.11

0.08

13

0.19

3.44

2.01

0.08

  1. ND Not detectable
  2. * Significantly different from sham-exposed animals (p < 0.05)