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Figure 3 | Particle and Fibre Toxicology

Figure 3

From: Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos

Figure 3

Cell profile in BAL fluids of C57BL/6 mice after pharyngeal aspiration with CNF, Crocidolite Asbestos, or SWCNT. A: polymorphonuclear leukocytes (PMNs); B: alveolar macrophages (AMs). Open columns - exposure with SWCNT (40 μg/mouse); gray columns - exposure with CNF (120 μg/mouse); black columns - exposure with crocidolite asbestos (120 μg/mouse). Mice were exposed via pharyngeal aspiration to doses indicated. Animals were sacrificed 1, 7, and 28 days post exposure. Average control (PBS-treated mice) values for PMNs (cells, x103) on day 1, 7 or 28 post exposure were 1.58 ± 0.69, 1.39 ± 0.45 or 0.71 ± 0.24, respectively. Average control values for AMs (cells, x103) on day 1, 7 or 28 post exposure were 389.06 ± 22.80, 345.01 ± 30.01 or 229.79 ± 27.81, respectively. Means ± SE (n = 6 mice per group). *p < 0.05 vs. control mice, αp < 0.05 vs. mice exposed to CNF, βp < 0.05 vs. mice exposed to asbestos.

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