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Figure 1 | Particle and Fibre Toxicology

Figure 1

From: Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages

Figure 1

TEM showing MWCNTs engulfed by RAW264.7 macrophages in vitro. Cells were treated with MWCNTs (50 μg/ml) for 24 hr in serum-free defined medium and then fixed and embedded in agar and TEM performed as described in Methods. Panel A: Low magnification showing two cells with MWCNTs within cytoplasm (arrows). Panel B: Higher magnification of the inset frame from Panel A showing agglomerated MWCNTs and an individual MWCNT in cytoplasm (arrows). Panel C: Magnification of left hand inset frame from Panel B showing individual MWCNT in cytoplasm. Panel D: Magnification of right hand inset frame from Panel B showing aggregated MWCNTs (arrows). Panel E: Cytotoxicity of MWCNT compared to CBNP in RAW264.7 cells as measured by LDH assay.

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