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Figure 5 | Particle and Fibre Toxicology

Figure 5

From: A mixture of anatase and rutile TiO2 nanoparticles induces histamine secretion in mast cells

Figure 5

Measurement of histamine secretion evoked by TiO 2 NPs. (A) ELISA quantification of histamine release from RBL-2H3 cells after TiO2 NP (0.1 mg/ml-0.75 mg/ml stimulation) in normal Hanks' solution (n ≥ 3, **p < 0.005). (B) Subsequent assessment of histamine secretion from RBL-2H3 cells when pre-treated with an intracellular Ca2+ chelator (BAPTA) and various blockers prior to TiO2 NP exposure (n ≥ 3; white, checkboard, and black bars represent 0, 0.5 and 0.75 mg/ml, respectively).

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