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Figure 2 | Particle and Fibre Toxicology

Figure 2

From: An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials

Figure 2

Effects of increasing concentration of NMs on the oxidation of DCFH to DCF in the presence of C3A cells. The C3A cells were exposed to cell medium (control) or NMs for 24 hr. Results are shown as mean fluorescence intensity minus corresponding control traces (± SEM) from three experiments (n = 3), significance indicated by * = p < 0.05 and ** = p < 0.005, when NM treatments are compared to the control. A) NM 101 B) NM 110 C) NM 111 D) NM 300 E) NM 400 F) NM 402 G) NRCWE 001 H) NRCWE 002 I) NRCWE 003 J) NRCWE 004. LC50 values are indicated for NMs where this value was measurable. For all other NMs the LC50 was not reached following exposure up to 80 μg/cm2 after a 24 hr incubation.

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