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Figure 5 | Particle and Fibre Toxicology

Figure 5

From: Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo

Figure 5

BSE images of differentiated THP-1 cells treated for 4 hours with AgNW. A) AgNW3 treated macrophages showed full phagocytosis of the nanowires. Only one nanowire could be visualised outside a cell (white arrow) and a few underneath the surface indicated by the black arrow. B) After AgNW5 treatment all nanowires were phagocytosed by cells after 4 hours (white arrow). C) A big proportion of AgNW10 appear membrane bound and therefore phagocytosed by cells (black/white arrow), however a few fibres could be seen protruding out of cells (white arrow). Frustrated phagocytosis was observed after AgNW14 (D) and AgNW28 (E) treatments, since most of fibres can be seen protruding out of the cells or shared between cells (white arrow and insert). BSE merged image with a scale bar of 10 μm and 5 μm for the inserts.

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