Figure 4

Graphs depicting the extent time- and dose-dependent cardiac ischemic reperfusion (I/R) injury following oropharyngeal aspiration of vehicle control 10% surfactant/saline (SS) and 3 forms of the MWCNT: Commercial grade (C-grade) Row A, carboxylated (COOH) Row B and nitrogen doped (N-doped) Row C. The cardiac I/R injuries were performed at 1 day (left most panels), 7 day (middle panels) and 28 day (right most panels) post aspiration of 100 μl of the MWCNT suspension. Data are reported as mean ± sem with an n = 6. * indicates statistical significance from the SS group, § from 0.01 μg, † from 0.1 μg ‡ from 1.0 μg and # from 10 μg dosing as determined by ANOVA with TUKEY post hoc analysis with significance at p < 0.05.