Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes

Table 6 Serum Cytokine Profile 1 Day post Oropharyngeal Aspiration of 100 μg MWCNTs (pg/ml)

Cytokine/Treatment	SS	C-grade	COOH	N-doped
Eotaxin	306.4 ± 75.0	276.9 ± 42.3	903.8 ± 278.6*	302.6 ± 22
IL-5	16.3 ± 1.1	30.3 ± 10.0	11.6 ± 3.0	51.2 ± 28.3
IL-6	9.2 ± 1.3	16.1 ± 7.8	137.8 ± 66.0	42.4 ± 26.4
IL-10	8.5 ± 1.9	8.6 ± 3.4	24.6 ± 15.4	125.8 ± 118.1
IL-12 (p40)	17.5 ± 3.6	20.3 ± 5.3	16.3 ± 2.2	12.6 ± 2.2
IL-12 (p70)	35 ± 5.9	55.3 ± 34.9	22.9 ± 3.1	516.7 ± 464.5
IL-13	446.3 ± 41.6	326.9 ± 38.2	365.3 ± 45.6	848.3 ± 490.0
KC	173.2 ± 32.6	97.1 ± 7.1	645.1 ± 441.3	183.5 ± 53.1
MCP-1	39.6 ± 12.3	36.6 ± 8.6	46.6 ± 6.0	136.1 ± 104.4
MIP1α	38.2 ± 9.3	71.1 ± 4.5	42.0 ± 4.4	128.1 ± 86.9
MIP-1β	129.0 ± 11.4	70.2 ± 22.3	82.8 ± 29.6	136.2 ± 48.8
MIP-2	155.4 ± 27.7	86.4 ± 43.8	209.1 ± 38.9	102.4 ± 26.4
RANTES	30.7 ± 5.8	36.1 ± 6.4	57.5 ± 12.0	65.9 ± 38.5
†IL-1β	33.25 ± 3.83	222.86 ±114.71	127.66 ± 45.32	47.25 ± 7.36
†TNF-α	N.D.	N.D.	N.D.	N.D.

Serum cytokine profile by Lincoplex Cytokine/Chemokine 20 plex kit 1 day post oropharyngeal aspiration of three forms of MWCNTs at 100 μg and vehicle control SS (10% surfactant saline). Data reported as mean ± SEM for n = 4. * indicates significance from SS, P ≤ 0.05.
† IL-1β and TNF-α profile 1 day post oropharyngeal aspiration of three forms of MWCNTs at 100 μg and vehicle control SS (10% surfactant saline) by ELISA. Data reported as mean ± SEM for n = 6. N.D. not detected, P ≤ 0.05 by one way- ANOVA.

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