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Table 2 BAL fluid counts in mice.

From: Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint

  

Control

 

NanoTiO2

  

Indoor-R

  

Indoor-NanoTiO2

 

1 day

  

18 μg

54 μg

162 μg

54 μg

162 μg

486 μg

54 μg

162 μg

486 μg

 

Neutrophils (x103)

7.7 ± 1.7

4.9 ± 1.5

56.8 ± 7.2***

189.9 ± 29.1***

14.2 ± 3.5

61.7 ± 17.8**

176.5 ± 18.8***

19.7 ± 3.5

58.2 ± 10.5**

170.4 ± 25.3***

 

Macrophages (x103)

53.2 ± 2.5

64.1 ± 6.9

56.4 ± 5.8

41.4 ± 6.2

61.1 ± 7.7

69.5 ± 4.1

78.9 ± 13.1

73.0 ± 7.1

68.8 ± 6.6

51.4 ± 7.2

 

Eosinophils (x103)

0.3 ± 0.4

0.3 ± 0.2

1.3 ± 0.7

2.1 ± 0.6

0.2 ± 0.1

2.0 ± 1.0

20.5 ± 3.1***

0.2 ± 0.2

1.3 ± 0.5

10.1 ± 5.4***

 

Lymphocytes (x103)

1.6 ± 0.2

1.2 ± 0.5

1.0 ± 0.3

2.4 ± 1.0

0.7 ± 0.2

2.1 ± 0.8

3.4 ± 1.4

0.9 ± 0.2

2.2 ± 0.8

2.7 ± 1.0

 

Total BAL cells (x103)

74.0 ± 3.6

77.6 ± 8.8

123 ± 12.8**

246.5 ± 31.1***

85.4 ± 8.2

146.4 ± 22.1***

298.8 ± 25.5***

106.3 ± 9.5

139.2 ± 14.2***

256.3 ± 29.5***

3days

           
 

Neutrophils (x103)

3.0 ± 2.3

0.9 ± 0.5

6.5 ± 1.0**

78.1 ± 10.5***

2.6 ± 1.9

4.4 ± 1.6

17.4 ± 2.7***

1.5 ± 0.5

3.7 ± 0.9

21.4 ± 5.3***

 

Macrophages (x103)

56.4 ± 4.2

58.9 ± 8.5

57.3 ± 6.9

84.2 ± 0.8

56.5 ± 6.2

69.7 ± 6.3

128.9 ± 8.2***

69.2 ± 7.9

85.6 ± 5.6*

106.6 ± 6.8***

 

Eosinophils (x103)

0.4 ± 0.6

0.5 ± 0.2

0.9 ± 0.3

9.7 ± 6.5

4.8 ± 0.4

8.4 ± 2.2***

45.0 ± 8.3***

0.9 ± 0.3

7.9 ± 3.8***

19.0 ± 7.5***

 

Lymphocytes (x103)

0.9 ± 0.2

0.8 ± 0.3

0.8 ± 0.2

4.6 ± 1.8

1.5 ± 0.7

6.7 ± 1.6***

14.1 ± 4.4***

1.3 ± 0.3

2.9 ± 1.3

8.5 ± 3.4*

 

Total BAL cells (x103)

69.1 ± 6.4

66.9 ± 8.6

71.8 ± 8.3

185.3 ± 14.0***

69.3 ± 6.6

99.4 ± 7.6

221.4 ± 17.2***

81.0 ± 8.2

109.3 ± 4.8***

174.9 ± 19.4***

28 days

          
 

Neutrophils (x103)

1.2 ± 0.2

1.1 ± 0.3

2.8 ± 0.6

14.7 ± 2.7***

0.6 ± 0.4

1.2 ± 0.4

1.4 ± 0.2

1.1 ± 0.4

1.8 ± 0.9

6.6 ± 2.0

 

Macrophages (x103)

82.4 ± 5.7

79.5 ± 5.4

71.8 ± 10.7

106.2 ± 14.6

54.1 ± 3.6

64.0 ± 3.6

91.2 ± 13.3

94.6 ± 23.5

92.8 ± 6.1

141.5 ± 30.4

 

Eosinophils (x103)

0.3 ± 0.0

0.5 ± 0.5

1.6 ± 0.0

1.2 ± 1.1

0.0 ± 0.0

1.9 ± 1.5

0.1 ± 0.1

0.07 ± 0.07

0.7 ± 0.6

3.2 ± 2.9

 

Lymphocytes (x103)

2.1 ± 0.4

2.0 ± 0.4

3.8 ± 1.0

18.4 ± 3.8

1.4 ± 0.4

2.8 ± 0.6

5.0 ± 1.3

2.0 ± 1.0

1.6 ± 0.5

5.8 ± 2.4

 

Total BAL cells (x103)

95.9 ± 5.8

94.1 ± 6.9

85.8 ± 11.6

154.7 ± 16.0*

62.5 ± 3.9

79.5 ± 4.9

108.8 ± 13.0

104.6 ± 25.0*

107.9 ± 6.0

173.6 ± 28.6**#

  1. BAL fluid counts in mice. 1, 3 and 28 days post-exposure to 18 μg, 54 μg and 162 μg NanoTiO2, 54 μg, 162 μg and 486 μg sanding dusts and control mice. *, **, ***: Statistically significant compared to control mice at the 0.5, 0.01 and 0.001 level, respectively. #: Statistically significant difference between the two paints at the 0.05 level
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Particle and Fibre Toxicology

ISSN: 1743-8977

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