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Table 3 Type and incidence of histopathological lesions.

From: Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint

Type of lesion/post-treatment day

Control

Nano TiO2

Indoor-Nano TiO2

Indoor-R

Printex 90

Foci (small) of inflammatory cells

     

   Day 1

0/3a

1/4

0/6

0/6

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

1/5

0/5

0/5

0/6

Polymorphonuclear cell foci

     

   Day 1

0/3

0/4

0/6

0/6

1/4

   Day 3

0/3

0/4

0/5

0/6

2/4

   Day 28

0/5

0/5

0/5

0/5

2/6

Hyperplasia of connective tissue perivascular

     

   Day 1

0/3

1/4

0/6

0/6

0/4

   Day 3

0/3

1/4

0/5

0/6

0/4

   Day 28

0/5

1/5

0/5

0/5

0/6

Hyperplasia of connective tissue near bile ductules or venules

     

   Day 1

0/3

0/4

0/6

0/5

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

0/5

0/5

0/5

3/6

Necrosis in centrilobular area

     

   Day 1

0/3

0/4

0/6

0/6

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

3/5

0/5

0/5

0/6

Microfoci of necrosis in centrilobular area

     

   Day 1

0/3

0/4

0/6

0/6

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

0/5

0/5

0/5

1/6

Eosinophilic necrosis in single hepatocytes

     

   Day 1

0/3

0/4

0/6

0/6

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

0/5

0/5

0/5

1/6

Hepatocytes with pycnotic nuclei

     

   Day 1

0/3

0/4

0/6

0/6

1/4

   Day 3

0/3

0/4

0/5

0/6

1/4

   Day 28

0/5

0/5

0/5

0/5

1/6

Parenchymal degeneration

     

   Day 1

0/3

0/4

0/6

0/6

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

2/5

0/5

0/5

3/6

Binucleate hepatocytes

     

   Day 1

0/3

1/4

0/6

0/5

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

0/5

0/5

0/5

2/6

Oedema of endothelial cells of portal venules

     

   Day 1

0/3

0/4

0/5

0/6

0/4

   Day 3

0/3

0/4

0/5

0/6

0/4

   Day 28

0/5

0/5

0/6

0/5

2/6

Increased number of Kupffer cellsb

     

   Day 1

0/3

2/4

0/6

0/6

1/4

   Day 3

0/3

2/4

0/5

0/6

1/4

   Day 28

0/5

2/5

0/5

0/5

2/6

  1. Type and incidence of histopathological lesions in the control mice and mice exposed to 162 μg of NanoTiO2, 486 μg Indoor-NanoTiO2, 486 μg Indoor-R, or 162 μg of Printex 90. a: Incidence of a lesion expressed as a number of livers with the lesion of a total number of examined livers. b: Qualitative evaluation only.