From: Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint
Type of lesion/post-treatment day | Control | Nano TiO2 | Indoor-Nano TiO2 | Indoor-R | Printex 90 |
---|---|---|---|---|---|
Foci (small) of inflammatory cells | |||||
Day 1 | 0/3a | 1/4 | 0/6 | 0/6 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 1/5 | 0/5 | 0/5 | 0/6 |
Polymorphonuclear cell foci | |||||
Day 1 | 0/3 | 0/4 | 0/6 | 0/6 | 1/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 2/4 |
Day 28 | 0/5 | 0/5 | 0/5 | 0/5 | 2/6 |
Hyperplasia of connective tissue perivascular | |||||
Day 1 | 0/3 | 1/4 | 0/6 | 0/6 | 0/4 |
Day 3 | 0/3 | 1/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 1/5 | 0/5 | 0/5 | 0/6 |
Hyperplasia of connective tissue near bile ductules or venules | |||||
Day 1 | 0/3 | 0/4 | 0/6 | 0/5 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 0/5 | 0/5 | 0/5 | 3/6 |
Necrosis in centrilobular area | |||||
Day 1 | 0/3 | 0/4 | 0/6 | 0/6 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 3/5 | 0/5 | 0/5 | 0/6 |
Microfoci of necrosis in centrilobular area | |||||
Day 1 | 0/3 | 0/4 | 0/6 | 0/6 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 0/5 | 0/5 | 0/5 | 1/6 |
Eosinophilic necrosis in single hepatocytes | |||||
Day 1 | 0/3 | 0/4 | 0/6 | 0/6 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 0/5 | 0/5 | 0/5 | 1/6 |
Hepatocytes with pycnotic nuclei | |||||
Day 1 | 0/3 | 0/4 | 0/6 | 0/6 | 1/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 1/4 |
Day 28 | 0/5 | 0/5 | 0/5 | 0/5 | 1/6 |
Parenchymal degeneration | |||||
Day 1 | 0/3 | 0/4 | 0/6 | 0/6 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 2/5 | 0/5 | 0/5 | 3/6 |
Binucleate hepatocytes | |||||
Day 1 | 0/3 | 1/4 | 0/6 | 0/5 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 0/5 | 0/5 | 0/5 | 2/6 |
Oedema of endothelial cells of portal venules | |||||
Day 1 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 3 | 0/3 | 0/4 | 0/5 | 0/6 | 0/4 |
Day 28 | 0/5 | 0/5 | 0/6 | 0/5 | 2/6 |
Increased number of Kupffer cellsb | |||||
Day 1 | 0/3 | 2/4 | 0/6 | 0/6 | 1/4 |
Day 3 | 0/3 | 2/4 | 0/5 | 0/6 | 1/4 |
Day 28 | 0/5 | 2/5 | 0/5 | 0/5 | 2/6 |