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Table 3 Type and incidence of histopathological lesions.

From: Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint

Type of lesion/post-treatment day Control Nano TiO2 Indoor-Nano TiO2 Indoor-R Printex 90
Foci (small) of inflammatory cells      
   Day 1 0/3a 1/4 0/6 0/6 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 1/5 0/5 0/5 0/6
Polymorphonuclear cell foci      
   Day 1 0/3 0/4 0/6 0/6 1/4
   Day 3 0/3 0/4 0/5 0/6 2/4
   Day 28 0/5 0/5 0/5 0/5 2/6
Hyperplasia of connective tissue perivascular      
   Day 1 0/3 1/4 0/6 0/6 0/4
   Day 3 0/3 1/4 0/5 0/6 0/4
   Day 28 0/5 1/5 0/5 0/5 0/6
Hyperplasia of connective tissue near bile ductules or venules      
   Day 1 0/3 0/4 0/6 0/5 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 0/5 0/5 0/5 3/6
Necrosis in centrilobular area      
   Day 1 0/3 0/4 0/6 0/6 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 3/5 0/5 0/5 0/6
Microfoci of necrosis in centrilobular area      
   Day 1 0/3 0/4 0/6 0/6 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 0/5 0/5 0/5 1/6
Eosinophilic necrosis in single hepatocytes      
   Day 1 0/3 0/4 0/6 0/6 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 0/5 0/5 0/5 1/6
Hepatocytes with pycnotic nuclei      
   Day 1 0/3 0/4 0/6 0/6 1/4
   Day 3 0/3 0/4 0/5 0/6 1/4
   Day 28 0/5 0/5 0/5 0/5 1/6
Parenchymal degeneration      
   Day 1 0/3 0/4 0/6 0/6 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 2/5 0/5 0/5 3/6
Binucleate hepatocytes      
   Day 1 0/3 1/4 0/6 0/5 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 0/5 0/5 0/5 2/6
Oedema of endothelial cells of portal venules      
   Day 1 0/3 0/4 0/5 0/6 0/4
   Day 3 0/3 0/4 0/5 0/6 0/4
   Day 28 0/5 0/5 0/6 0/5 2/6
Increased number of Kupffer cellsb      
   Day 1 0/3 2/4 0/6 0/6 1/4
   Day 3 0/3 2/4 0/5 0/6 1/4
   Day 28 0/5 2/5 0/5 0/5 2/6
  1. Type and incidence of histopathological lesions in the control mice and mice exposed to 162 μg of NanoTiO2, 486 μg Indoor-NanoTiO2, 486 μg Indoor-R, or 162 μg of Printex 90. a: Incidence of a lesion expressed as a number of livers with the lesion of a total number of examined livers. b: Qualitative evaluation only.