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Figure 3 | Particle and Fibre Toxicology

Figure 3

From: Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model

Figure 3

Exposure to CAPs, Ni, or CAPs+Ni induces increased monocytic cell infiltration and reduces UCP1 expression . A and B, Representative images (A) and statistical analysis (B) of immunohistochemistry for F4/80+ macrophages in the lung and eWAT, and UCP1 expression in the pBAT and iBAT depots. Original magnification, ×200. N = 5–6. * P < 0.05 vs. FA; ** P < 0.001 vs. FA; † P < 0.05 vs. Ni group. C, Western blotting for UCP1 expression in interscapular adipose tissue. Upper panel shows the representative western blotting bands, and lower panel is the statistical analysis. N = 5–6. * P < 0.05 vs. FA group. iBAT, interscapular brown adipose tissue; pBAT, perivascular brown adipose tissue.

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