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Figure 1 | Particle and Fibre Toxicology

Figure 1

From: Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells — implications for susceptibility to traffic-related air pollution

Figure 1

Exposure time line. (A) Confluent LA-4 epithelial cells treated with cytomix (TNFα + IL-1β + IFNγ) × 24 h followed by DEP (25 μg/cm2) for 2 h (fluorescent end points) or 24 h (cytoxicity). (B) Exposure time line for BALB/c mice treated via oropharyngeal aspiration with PBS or cytomix (Day 0); exposed to air or DEP (2 mg/m3 4 h/d × 2 d) (Day 2 and 3) and necropsied on Day 4. A subset of mice received FeTMPyP systemically (10 mg/kg, i.p.) (Day −1 to 4).

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