Table 4 BAL fluid indices and lung glutathione ratios in saline- or cytomix-treated mice, 24 h after exposure to air or DEP for 2 consecutive days
Air | DEP | |||||
|---|---|---|---|---|---|---|
N = 4/group | Saline | Cytomix | FeTMPyP: Cytomix | Saline | Cytomix | FeTMPyP: Cytomix |
BAL fluid cells per lung (x10 3 ) | ||||||
Total Cells | 110 ± 52 | 96.4 ± 22 | 109 ± 11 | 84.8 ± 21 | 107 ± 35 | 84.3 ± 10 |
Macrophages | 101 ± 44 | 89.3 ± 20 | 101 ± 11 | 83.2 ± 21 | 96.4 ± 33 | 78.0 ± 9.1 |
Neutrophils | 0.6 ± 0.10 | 4.1 ± 1.8 | 5.5 ± 1.5 | 0.4 ± 0.1 | 7.5 ± 2.6 | 4.7 ± 0.8 |
Lymphocytes | 0.9 ± 0.6 | 3.0 ± 0.7 | 3.0 ± 1.2 | 1.2 ± 0.5 | 2.8 ± 0.7 | 1.6 ± 0.7 |
BAL fluid Biochemistries | ||||||
LDH (U/mL) | 37.0 ± 9.8 | 38.8 ± 8.6 | 38.1 ± 1.6 | 23.5 ± 1.3 | 43.7 ± 6.7 | 36.4 ± 2.6 |
Total Protein (μg/mL) | 66.8 ± 17.8 | 82.0 ± 8.4 | 74.2 ± 1.7 | 68.1 ± 2.4 | 88.1 ± 16.9 | 75.9 ± 2.3 |
Albumin (μg/mL) | 15.9 ± 3.1 | 16.6 ± 0.5 | 14.1 ± 0.8 | 16.9 ± 0.4 | 14.7 ± 1.7 | 14.7 ± 0.6 |
Lung GSH:GSSG | 3.9 ± 0.4 | 3.1 ± 0.6 | 1.7 ± 0.1 | 9.9 ± 1.2* | 9.2 ± 1.8* | 8.8 ± 1.4* |