Figure 3

Lung histology 24 hour post aspiration to AgNW panel and controls. H&E stained lung sections at lower (left) and higher (right) magnification show normal alveolar structure in the vehicle control (A), SFA (B) and AgNW₃ (D) sections. Small accumulations of inflammatory cells were seen after AgNW₅ (E) and AgNW₁₀ (F) exposure whereas a greater amount of inflammatory cell infiltration in the alveoli, peribronchiolar and perivascular regionswere observed after LFA (C) and AgNW₁₄ (G). The white arrows are indicating the areas of fibre accumulation. Abbreviations: al, alveolus; br, bronchiole; v, blood vessel. Representative images are shown, similar results are obtained from 2 mice.