Table 1 BAL fluid cell counts and distribution of cells by type (%) in C57BL/6 mice 1, 3 and 28 days post-exposure to 0.018, 0.054 and 0.162 mg Printex 90 CBNPs and control mice. *, ** refers to a statistical significance of P < 0.05 and P < 0.001 respectively.
| Â | Â | Control | 0.018 mg | 0.054 mg | 0.162 mg |
|---|---|---|---|---|---|
24 h | Â | Â | Â | Â | Â |
|  | Neutrophils x10 3 (%) | 7.7 ± 1.7 (9.8) | 65.0 ± 20.0 (44.3) ** | 140.0 ± 28.0 (61.5) ** | 160.0 ± 18.0 (73.9) ** |
|  | Macrophages x10 3 (%) | 53.0 ± 2.5 (73.1) | 53.0 ± 6.8 (47.2) | 50.0 ± 6.3 (31.4) | 37.0 ± 5.8 (16.9) ** |
|  | Eosinophils x10 3 (%) | 0.3 ± 0.4 (0.3) | 1.1 ± 0.4 (0.8) | 3.1 ± 2.1 (1.3) | 4.2 ± 2.6 (1.6) |
|  | Lymphocytes x10 3 (%) | 1.5 ± 0.2 (2.2) | 1.4 ± 0.6 (0.9) | 2.5 ± 0.7 (1.3) | 1.7 ± 0.9 (0.8) |
|  | Total BAL Cells x10 3 | 74.0 ± 3.6 | 130.0 ± 16.7 ** | 200.0 ± 28.0 ** | 220.0 ± 24.0 ** |
3 days | Â | Â | Â | Â | Â |
|  | Neutrophils x10 3 (%) | 3.0 ± 2.3 (2.4) | 21.0 ± 5.9 (16.2) ** | 63.0 ± 4.8 (40.5) ** | 120.0 ± 13.0 (46.7) ** |
|  | Macrophages x10 3 (%) | 56.0 ± 4.2 (83.1) | 86.0 ± 12.0 (65.8) * | 63.0 ± 6.9 (40.3) | 89.0 ± 12.0 (33.4) * |
|  | Eosinophils x10 3 (%) | 0.4 ± 0.6 (0.6) | 13.0 ± 5.8 (8.8) ** | 16.0 ± 4.3 (10.4) ** | 29.0 ± 9.9 (10.8) ** |
|  | Lymphocytes x10 3 (%) | 0.9 ± 0.2 (1.4) | 3.8 ± 1.0 (2.9) ** | 4.3 ± 1.0 (2.8) ** | 8.4 ± 1.8 (3.3) ** |
|  | Total BAL Cells x10 3 | 69.0 ± 6.4 | 130.0 ± 15.0 ** | 160.0 ± 22.0 ** | 270.0 ± 24.0 ** |
28 days | Â | Â | Â | Â | Â |
|  | Neutrophils x10 3 (%) | 1.2 ± 0.2 (1.2) | 3.1 ± 0.5 (3.4) * | 15.0 ± 3.1 (10.9) ** | 50.0 ± 13.0 (29.3) ** |
|  | Macrophages x10 3 (%) | 82.0 ± 5.7 (85.6) | 73.0 ± 9.4 (77.5) | 99.0 ± 15.0 (73.3) | 75.0 ± 4.3 (48.4) |
|  | Eosinophils x10 3 (%) | 0.3 ± 0.0 (0.3) | 3.4 ± 3.4 (2.8) | 0.1 ± 0.1 (0.1) | 0.1 ± 0.1 (0.1) |
|  | Lymphocytes x10 3 (%) | 2.1 ± 0.4 (2.2) | 3.5 ± 1.2 (4.1) | 12.0 ± 2.7 (8.9) ** | 22.0 ± 6.1 (13.4) ** |
|  | Total BAL Cells x10 3 | 96.0 ± 5.8 | 93.0 ± 10.0 | 140.0 ± 21.0 ** | 160.0 ± 16.0 ** |