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Figure 5 | Particle and Fibre Toxicology

Figure 5

From: Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells

Figure 5

Bio-Plex analysis of secreted cytokines and chemokines in medium of BEAS 2B cells exposed to silica particles 24 h. Cell-free conditioned medium of BEAS 2B exposed to silica particles for 24 h was assayed for 27 cytokines and chemokines. Presented in this panel are the 11 which yielded significant differences from untreated controls in levels of secreted proteins: Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-12 (p70) (IL-12 (p70)), Interleukin-13 (IL-13), Interleukin-15 (IL-15), Monocyte chemotactic protein-1 (MCP-1 or MCAF), Regulated upon activation, normal T-cell expressed and secreted (RANTES), Granulocyte-colony stimulating factor (G-CSF), Basic fibroblast growth factor (bFGF), Platelet derived growth factor-BB (PDGF-BB) and Vascular endothelial growth factor (VEGF). White bars (unexposed controls), black bars (cristobalite silica) and gray bars (amorphous silica), N = 3. * (P < 0.05) vs. unexposed controls, †P < 0.05 vs. amorphous silica.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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