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Table 3 Top 10 genes affected by 24 h exposure to silica particles in NHBE

From: Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells

Gene Name (Abbreviation)

Fold Changea

 

Cristobalite

Amorphous

 

15 b

75 b

75 b

Up-regulated â–²

   

Interleukin 8 (IL8)

4.37

28.47

NC

Baculoviral IAP repeat-containing 3 (BIRC3)

2.02

19.81

NC

BCL2-related protein A1 (BCL2A1)

NC

19.27

NC

Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3)

2.33

17.11

NC

Interleukin 1 family, member 9 (IL1F9)

NC

14.14

NC

GTP binding protein over expressed in skeletal muscle (GEM)

NC

12.92

NC

CD83 molecule (CD83)

NC

11.47

NC

Transcribed locus, strongly similar to NP_006463.2 thioredoxin interacting protein

NC

11.09

27.95

Inhibin, beta A (INHBA)

NC

10.25

NC

Thioredoxin interacting protein (TXNIP)

NC

9.74

31.14

Heat shock 70 kDa protein 1A (HSPA1A)

2.01

7.56

2.57

Crystallin, mu (CRYM)

NC

4.97

2.35

G0/G1 switch 2 (G0S2)

NC

3.51

3.12

Transcribed locus (BF4328873)

NC

NC

2.73

Calcium binding tyrosine-(Y)-phosphorylation regulated (CABYR)

NC

2.51

2.55

Non-protein coding RNA 84 (NCRNA00084)

NC

NC

2.53

Sarcoglycan, gamma (35 kDa dystrophin-associated glycoprotein) (SGCG)

NC

NC

2.50

Cytoplasmic FMR1 interacting protein 2 (CYFIP2)

NC

NC

2.48

Down-regulated â–¼

   

Sulfatase (SULF1)

NC

3.59

NC

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A)

NC

3.52

NC

Solute carrier family 38, member 4 (SLC38A4)

NC

3.43

NC

Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 (ALS2CR8)

NC

3.18

2.00

Growth arrest-specific 1 (GAS1)

NC

2.84

NC

Hexokinase 2 (HK2)

NC

2.69

NC

F-box protein 9 (FBXO9)

NC

2.68

NC

Hairy/enhancer-of-split related with YRPW motif 1 (HEY1)

NC

2.62

NC

CDNA FLJ37852 fis, clone BRSSN2014513

NC

2.61

NC

Growth hormone receptor (GHR)

NC

2.59

NC

Solute carrier family 16, member 7 (monocarboxylic acid transporter 2) (SLC16A7)

NC

2.50

NC

Transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) (TGM3)

2.13

NC

NC

Follistatin (FST)

NC

NC

2.43

Homo sapiens clone FLB9440 PRO2550 mRNA, complete cds

NC

2.32

2.18

Ribonucleotide reductase M2 polypeptide (RRM2)

NC

NC

2.12

PPPDE peptidase domain containing 1 (PPPDE1)

NC

2.23

2.06

  1. Top 10 genes in NHBE cells up and down-regulated by 24-hour exposure to cristobalite silica at 15 and 75 × 106 μm2/cm2 and amorphous silica particles at 75 × 106 μm2/cm2.
  2. a Fold change (mRNA) expression (p < 0.05) cut-off ≥ 2.0-fold compared to controls (n = 3).
  3. b Silica particle concentrations: (× 106μm2/cm2)
  4. NC = No Change
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Particle and Fibre Toxicology

ISSN: 1743-8977

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