From: Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function
Clean air | Low level wood smoke exposure | High level wood smoke exposure | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Before | 0 h | 6 h | 20 h | Before | 0 h | 6 h | 20 h | Before | 0 h | 6 h | 20 h | |
Gene expression | ||||||||||||
CCL2 | 0.08 ± 0.04 | 0.05 ± 0.02 | 0.06 ± 0.02 | 0.10 ± 0.05 | 0.15 ± 0.09 | 0.18 ± 0.10 | 0.12 ± 0.05 | 0.02 ± 0.02 | 0.06 ± 0.02 | 0.14 ± 0.09 | 0.16 ± 0.08 | 0.22 ± 0.11 |
ITGAL | 52.9 ± 22.5 | 57.0 ± 28.4 | 70.2 ± 33.6 | 173 ± 108 | 206 ± 172 | 203 ± 135 | 81.3 ± 36.4 | 15.8 ± 3.99 | 72.7 ± 37.6 | 46.8 ± 22.9 | 49.6 ± 17.0 | 86.01 ± 51.7 |
TNF | 75.1 ± 73.0 | 4.10 ± 1.64 | 4.31 ± 1.48 | 8.14 ± 2.86 | 7.43 ± 3.46 | 8.91 ± 3.74 | 4.78 ± 1.49 | 2.35 ± 1.60 | 3.61 ± 1.63 | 2.42 ± 0.99 | 59.0 ± 57.2 | 68.7 ± 66.3 |
IL6 | 0.07 ± 0.06 | 0.03 ± 0.01 | 0.05 ± 0.03 | 0.08 ± 0.05 | 0.14 ± 0.10 | 0.24 ± 0.15 | 0.15 ± 0.09 | 0.01 ± 0.00 | 0.05 ± 0.02 | 0.03 ± 0.01 | 0.11 ± 0.09 | 0.42 ± 0.38 |
IL8 | 0.11 ± 0.06 | 0.03 ± 0.01 | 0.03 ± 0.01 | 0.05 ± 0.02 | 0.09 ± 0.04 | 0.19 ± 0.10 | 0.14 ± 0.09 | 0.02 ± 0.01 | 0.06 ± 0.02 | 0.09 ± 0.06 | 0.07 ± 0.04 | 0.06 ± 0.03 |
HMOX1 | 2.13 ± 0.54 | 4.69 ± 2.01 | 3.86 ± 1.48 | 5.00 ± 1.94 | 4.36 ± 1.97 | 6.17 ± 2.65 | 4.07 ± 1.24 | 1.12 ± 0.28 | 7.67 ± 4.72 | 3.41 ± 1.15 | 2.95 ± 0.56 | 2.76 ± 0.77 |
OGG1 | 3.69 ± 2.37 | 2.47 ± 1.44 | 2.56 ± 1.33 | 3.28 ± 1.67 | 2.82. ± 1.54 | 5.17 ± 2.43 | 4.81 ± 1.78 | 1.85 ± 1.14 | 3.35 ± 2.08 | 2.65 ± 1.06 | 6.33 ± 3.30 | 6.31 ± 14.3 |
Adhesion molecules | ||||||||||||
ICAM1 | 122 ± 3.34 | 123 ± 3.16 | 118 ± 3.40 | 120 ± 4.26 | 122 ± 15.6 | 119 ± 2.11 | 124 ± 2.56 | 124 ± 2.45 | 117 ± 2.72 | 122 ± 3.84 | 121 ± 2.82 | 123 ± 3.03 |
ITGAL | 114 ± 9.13 | 117 ± 9.60 | 104 ± 16.5 | 130 ± 4.26 | 121 ± 3.49 | 109 ± 9.19 | 120 ± 9.16 | 111 ± 9.20 | 114 ± 10.8 | 105 ± 9.63 | 115 ± 10.5 | 123 ± 11.8 |
L-Selectin | 227 ± 24.3 | 146 ± 11.4 | 159 ± 16.5 | 157 ± 11.9 | 234 ± 17.9 | 196 ± 15.1 | 202 ± 14.0 | 262 ± 31.8 | 223 ± 28.3 | 205 ± 19.4 | 189 ± 18.5 | 155 ± 13.5 |