Table 3 Ex vivo contractile and relaxant responses in arterial rings isolated 6 and 24 h after instillation of rats with diesel exhaust particles (DEP) or saline

logEC ₅₀

Max

(% response to KCl)

logIC ₅₀

Imax

(% preconstriction)

logIC ₅₀

Imax

(% preconstriction)

logIC ₅₀

Imax

(% preconstriction)

Aorta

6 h

saline

-7.24 ± 0.14

67.1 ± 8.1

-7.88 ± 0.20

94.9 ± 1.3

-8.67 ± 0.13

96.7 ± 1.0

-7.52 ± 0.15

90.0 ± 1.8

DEP

-7.03 ± 0.07

88.6 ± 5.1*

-7.75 ± 0.11

96.1 ± 1.4

-8.70 ± 0.11

87.9 ± 1.0

-8.07 ± 0.10*

93.1 ± 2.2

24 h

saline

-7.29 ± 0.13

120.8 ± 14.5

-7.52 ± 0.10

99.3 ± 0.5

-8.43 ± 0.13

99.3 ± 0.6

-7.62 ± 0.16

88.0 ± 5.8

DEP

-7.38 ± 0.11

115.3 ± 13.0

-7.67 ± 0.17

96.2 ± 1.5

-8.60 ± 0.10

98.9 ± 0.4

-7.62 ± 0.26

87.8 ± 6.4

Femoral Artery

6 h

saline

-5.59 ± 0.08

115.1 ± 24.2

-6.69 ± 0.11

68.9 ± 4.9

-7.80 ± 0.15

94.1 ± 2.9

-6.39 ± 0.29

67.3 ± 7.1

DEP

-5.53 ± 0.06

91.8 ± 4.0

-6.81 ± 0.14

77.2 ± 5.6

-7.81 ± 0.18

95.1 ± 1.9

-6.51 ± 0.27

77.4 ± 3.9

24 h

saline

-5.46 ± 0.24

136.0 ± 32.4

-6.79 ± 0.18

61.2 ± 4.7

-7.64 ± 0.18

92.7 ± 2.7

-7.03 ± 0.14

41.8 ± 4.8

DEP

-5.46 ± 0.09

124.2 ± 11.4

-6.86 ± 0.14

68.3 ± 6.3

-7.81 ± 0.18

92.5 ± 2.2

-7.07 ± 0.23

58.7 ± 6.5

Mesenteric Artery

6 h

saline

-6.02 ± 0.15

96.1 ± 3.6

-7.29 ± 0.27

76.4 ± 7.8

-7.82 ± 0.15

98.1 ± 2.2

-8.19 ± 0.17

101.3 ± 0.7

DEP

-5.76 ± 0.19

99.3 ± 3.9

-7.51 ± 0.11

88.4 ± 3.6

-8.36 ± 0.05**

98.3 ± 1.4

-8.80 ± 0.24

99.6 ± 1.2

24 h

saline

-6.19 ± 0.11

103.6 ± 5.9

-7.65 ± 0.23

82.0 ± 5.0

-8.40 ± 0.15

99.1 ± 1.1

-8.74 ± 0.16

102.4 ± 0.9

DEP

-6.07 ± 0.11

132.9 ± 13.1

-7.58 ± 0.17

80.6 ± 5.8

-8.28 ± 0.19

99.3 ± 3.4

-8.32 ± 0.21

102.5 ± 0.4