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Figure 5 | Particle and Fibre Toxicology

Figure 5

From: Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats

Figure 5

Expression analysis of lung transcripts associated with oxidative stress, endothelial activation and coagulation cascade in ultrafine carbon particle ( UfCP ) exposed spontaneously hypertensive rats (SHRs) compared to control on 1st(24 h ) and 3rd(72 h ) recovery day using quantitative real time polymerase chain reaction (qRTPCR). a. Transcript levels of Haemoygenase 1 (HO1) was significantly increased in UfCP exposed SHRs on 1st recovery day compared to control whereas at 3rd recovery day it remained unchanged. b. Transcript levels of endothelin 1 (ET1), was significantly increased in exposed SHRs on 1st recovery day compared to control whereas at 3rd recovery day it remained unchanged. c. Transcript levels of endothelin receptor A (ETA) was significantly increased in UfCP exposed SHRs on 1st recovery day compared to control whereas at third recovery day it remained unchanged. d. Transcript levels of endothelin receptor B (ETB) was significantly reduced in UfCP exposed SHRs on 1st recovery day compared to control whereas at 3rd recovery day it remained unchanged. e. Transcript levels of plasminogen activator inhibitor-1 (PAI1) were significantly reduced in UfCP exposed SHRs on both 1st and 3rd recovery days compared to control. f. Transcript levels of tissue factor (TF) were significantly increased on 1st recovery day and significantly reduced on 3rd recovery day in UfCP exposed SHRs compared to control. Data are represented as mean ± SE. (n?=?6/experimental group; *indicates p < 0.05; white bar: control; black bar: exposed.

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