Table 2 Comparison of ultrafine carbon particle (UfCP) induced cardiovascular and inflammatory effects and alterations of hematological parameters
From: Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats
Matrix | Adult SHRs (Age: 6–7 months) (Upadhyay et al.[[25]] | Aged SHRs (Age: 12–13 months) | ||
|---|---|---|---|---|
| Â | 1st-3rdrecovery day | 1strecovery day | ||
Cardiovascular | Control | UfCP exposed | Control | UfCP exposed |
BP (mmHg) | 176 ± 2.0 | 182 ± 2.1 ↑ (3.4%) | 181 ± 1.5 | 189 ± 1.8 ↑ (4.4%) |
HR (bpm) | 328 ± 3.5 | 345 ± 3.5 ↑ (5.2%) | 331 ± 3.2 | 352 ± 3.4 ↑ (6.3%) |
SDNN | 1.08 ± 0.05 | 0.77 ± 0.03 ↓ (30%) | 1.15 ± 0.07 | 0.81 ± 0.01 ↓ (36%) |
BAL | ||||
Total Cells (×106/ml) | 3.7 ± 0.2 | 4.7 ± 0.2 | 11.6 ± 1.3 | 16.4 ± 2.21 ↑ (41%) |
PMN (×106/ml) | 0.3 ± 0.1 | 0.4 ± 0.1 | 0.8 ± 0.1 | 1.3 ± 0.2 ↑ (58%) |
IL-6 (pg/ml), | 83 ± 6.2 | 92 ± 4.1 | 92 ± 2.8 | 115 ± 3.4 ↑ (25%) |
TNF-alpha (pg/ml) | Not detectable | Not detectable | 20.0 ± 2.0 | 24.4 ± 2.6 |
NAG | 5.3 ± 0.1 | 5.8 ± 0.1 | 4.5 ± 0.9 | 3.5 ± 0.2 |
Hematology | ||||
WBC (.103 cells/?l) | 6.19 ± 0.4 | 5.79 ± 0.5 | 5.27 ± 0.7 | 5.57 ± 0.21 |
PLT (103 cells/?l) | 436 ± 30.2 | 443.8 ± 48.4 | 379.5 ± 50.1 | 456.7 ± 25.6 ↑ (20%) |
Hematocrit | 44.8 ± 0.8 | 43.8 ± 2.1 | 43.6 ± 1.4 | 44.1 ± 0.4 |
Thrombocrit (%) | 0.51 ± 0.04 | 0.39 ± 0.05 | 0.38 ± 0.04 | 0.42 ± 0.02 |
Neutrophil (%) | 48.9 ± 2.2 | 39.2 ± 2.8 | 49.8 ± 4.04 | 43.9 ± 1.5 |
Lymphocyte (%) | 43.3 ± 3.1 | 56.3 ± 2.9 | 43.4 ± 4.4 | 49.3 ± 1.7 |
Systemic | ||||
HPT (serum, mg/dl) | 300 ± 17 | 309 ± 20 | 611 ± 17 | 710 ± 20 ↑ (16%) |
CRP (serum, ?g/ml) | 92 ± 3.8 | 94 ± 3.0 | 132.7 ± 10.2 | 209 ± 4.4 ↑ (58%) |
Fibrinogen (Plasma, mg/dl) | 190 ± 11.4 | 198 ± 5.2 | 191 ± 5 | 217 ± 8.0 ↑ (13.6%) |
Plasma renin concentration (PRC) | 1 st recovery day | 2 nd recovery day | Â | Â |
55 ± 7.0/120 ± 14.0 ↑ | 52 ± 4.0/70 ± 8.0 ↑ | 50 ± 13.4 | 39 ± 9 | |
Lung Transcript analysis (Expression in UfCP exposed SHRs compared to control) | 1 st recovery day | 3 rd recovery day | 1 st recovery day | |
HO-1 | NS | ↑2.5 fold | ↑2.0 fold | |
ET-1 | NS | ↑6.0 fold | ↑1.5 fold | |
ET-A | NS | ↑2.5 fold | ↑1.7 fold | |
ET-B | NS | ↑2.5 fold | NS↓0.5 fold | |
PAI-1 | ↑ | ↑2.5 fold | NS↓0.4 fold (3rd day) | |
TF | NS | ↑2.5 fold | ↑1.7 fold | |
Cardiac Transcript analysis (Expression in UfCP exposed SHRs compared to control) | 1 st recovery day | 3 rd recovery day | 1 st recovery day | |
HO-1 | NS | ?2.0 fold | NS | |
ET-1 | NS | NS | ↑1.5 fold | |
ET-A | NS | NS | NS | |
ET-B | NS | NS | NS | |
PAI-1 | NS | NS | NS | |
TF | NS | NS | NS | |