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Table 3 Post hoc sequence analysis of total and differential cell count in BAL

From: Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study

Sequence (A): 1 st Period: UFP – 2 nd Period: Filtered air
BAL Cells [106] UFP mean (allergen-saline) Filtered air mean (allergen-saline) Treatment effect (UFP-FA) 95%-confidence interval p-value
Total cells 13.4 75.1 −61.6 −110.4; −12.8 0.021
Eosinophils 13.2 64.1 −50.9 −95.5; −6.3 0.031
Monocytes 0.9 5.7 −4.8 −8.3; −1.4 0.013
Macrophages 0.3 6.9 −6.6 −18.7; 5.5 0.232
Neutrophils −0.8 1.9 −2.7 −7.6; 2.1 0.219
Lymphocytes 0.0 1.0 −1.0 −3.1; 1.2 0.313
Sequence (B): 1 st Period: Filtered air – 2 nd Period: UFP
BAL Cells [106] Filtered air mean (allergen-saline) UFP mean (allergen-saline) Treatment effect (UFP-FA) 95%-confidence interval p-value
Total cells 4.5 29.3 24.8 −33.2; 82.8 0.300
Eosinophils 3.7 26.1 22.5 −25.5; 70.4 0.263
Monocytes 0.4 3.5 3.2 −5.7; 12.0 0.377
Macrophages 0.6 0.7 0.1 −5.8; 6.0 0.951
Neutrophils 0.2 1.1 0.8 −2.2; 3.8 0.492
Lymphocytes −0.1 0.6 0.6 −1.9; 3.2 0.531
  1. Sequence analysis using t-test for two paired samples of the exposure sequence. (A) 1st Period: UFP – 2nd Period: Filtered air and (B) 1st Period: Filtered air – 2nd Period: UFP. Treatment differences between UFP and filtered air.