Figure 6

Tissue distribution of⁶⁵Zn post-gavage of⁶⁵ZnO and SiO ₂ -coated⁶⁵ZnO NPs. Data are % dose of administered ⁶⁵Zn in different organs. (A) At 5 minutes post-gavage, the ⁶⁵Zn levels in tissues other than the gastrointestinal tract were much lower (0.3% for uncoated, 0.05% for coated ⁶⁵ZnO NPs). (B) At day 7, significantly more ⁶⁵Zn was absorbed and retained in non-GIT tissues (6.9% for uncoated, 6.0% for coated ⁶⁵ZnO NPs). Significantly more ⁶⁵Zn was measured in skeletal muscle in rat gavaged with uncoated versus coated ⁶⁵ZnO NPs. (Note: RBC: red blood cell; sk muscl: skeletal muscle; sm int: small intestine: large int: large intestine).