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Table 1 Tissue distribution of 65 Zn at 2 days after intratracheal instillation of 65 ZnO or SiO 2 -coated 65 ZnO NPs in rats

From: Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

 

ZnO

SiO2-coated ZnO

 

Mean ± SE

Mean ± SE

Lungs

16.08 ± 2.00

18.09 ± 2.17

Blood

2.54 ± 0.07*

2.22 ± 0.08

Lymph nodes

0.63 ± 0.23

0.49 ± 0.04

Bone marrow

3.37 ± 0.32

2.89 ± 0.15

Bone

9.59 ± 0.46

9.25 ± 0.29

Skin

11.30 ± 1.00

12.52 ± 0.77

Brain

0.17 ± 0.01

0.19 ± 0.01 #

Skeletal muscle

14.22 ± 0.77*

6.39 ± 2.44

Testes

0.84 ± 0.05

0.78 ± 0.04

Kidneys

2.05 ± 0.07*

1.74 ± 0.03

Spleen

0.50 ± 0.02

0.44 ± 0.02

Heart

0.47 ± 0.04*

0.36 ± 0.01

Liver

12.23 ± 0.24*

9.88 ± 0.38

Stomach

1.01 ± 0.14

0.78 ± 0.02

Small intestine

7.37 ± 0.32

6.89 ± 0.20

Large intestine

2.08 ± 0.21

1.91 ± 0.12

Cecum

3.42 ± 0.22*

2.35 ± 0.25

Total recovered

87.78 ± 2.35*

76.78 ± 2.84

  1. Data are mean ± SE% instilled dose, n = 8/group.
  2. Total recovered = sum of 65Zn in analyzed organs, feces and urine.
  3. *P < 0.05, ZnO > SiO2-coated ZnO.
  4. # P <0.05, SiO2-coated ZnO > ZnO.