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Table 1 Tissue distribution of 65 Zn at 2 days after intratracheal instillation of 65 ZnO or SiO 2 -coated 65 ZnO NPs in rats

From: Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

  ZnO SiO2-coated ZnO
  Mean ± SE Mean ± SE
Lungs 16.08 ± 2.00 18.09 ± 2.17
Blood 2.54 ± 0.07* 2.22 ± 0.08
Lymph nodes 0.63 ± 0.23 0.49 ± 0.04
Bone marrow 3.37 ± 0.32 2.89 ± 0.15
Bone 9.59 ± 0.46 9.25 ± 0.29
Skin 11.30 ± 1.00 12.52 ± 0.77
Brain 0.17 ± 0.01 0.19 ± 0.01 #
Skeletal muscle 14.22 ± 0.77* 6.39 ± 2.44
Testes 0.84 ± 0.05 0.78 ± 0.04
Kidneys 2.05 ± 0.07* 1.74 ± 0.03
Spleen 0.50 ± 0.02 0.44 ± 0.02
Heart 0.47 ± 0.04* 0.36 ± 0.01
Liver 12.23 ± 0.24* 9.88 ± 0.38
Stomach 1.01 ± 0.14 0.78 ± 0.02
Small intestine 7.37 ± 0.32 6.89 ± 0.20
Large intestine 2.08 ± 0.21 1.91 ± 0.12
Cecum 3.42 ± 0.22* 2.35 ± 0.25
Total recovered 87.78 ± 2.35* 76.78 ± 2.84
  1. Data are mean ± SE% instilled dose, n = 8/group.
  2. Total recovered = sum of 65Zn in analyzed organs, feces and urine.
  3. *P < 0.05, ZnO > SiO2-coated ZnO.
  4. # P <0.05, SiO2-coated ZnO > ZnO.
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