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Table 3 Tissue distribution of 65 Zn at 28 days after intratracheal instillation of 65 ZnO or SiO 2 -coated 65 ZnO NPs in rats

From: Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

  65ZnO SiO2-coated65ZnO
  Mean ± SE Mean ± SE
Lungs 0.28 ± 0.05* 0.14 ± 0.01
Blood 0.79 ± 0.05* 0.61 ± 0.02
Lymph nodes 0.03 ± 0.005 0.12 ± 0.01 #
Bone marrow 2.30 ± 0.12 3.33 ± 0.15 #
Bone 12.40 ± 0.36 13.59 ± 0.52
Skin 4.72 ± 0.60* 3.26 ± 0.13
Brain 0.18 ± 0.02 0.15 ± 0.01
Skeletal muscle 13.27 ± 3.02* 0.66 ± 0.04
Testes 0.49 ± 0.03 0.46 ± 0.03
Kidneys 0.19 ± 0.01 0.17 ± 0.005
Spleen 0.05 ± 0.005 0.04 ± 0.003
Heart 0.07 ± 0.004* 0.06 ± 0.002
Liver 1.32 ± 0.09 1.14 ± 0.02
Stomach 0.20 ± 0.01 0.20 ± 0.01
Small intestine 0.63 ± 0.05 0.55 ± 0.01
Large intestine 0.19 ± 0.02 0.25 ± 0.01 #
Cecum 0.23 ± 0.02 0.24 ± 0.01
Total recovered 88.20 ± 4.36* 72.81 ± 0.53
  1. Data are mean ± SE% instilled dose, n = 5/group.
  2. Total recovered = sum of 65Zn in analyzed organs, feces and urine.
  3. *P < 0.05, ZnO > SiO2-coated ZnO.
  4. # P <0.05, SiO2-coated ZnO > ZnO.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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