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Table 3 Tissue distribution of 65 Zn at 28 days after intratracheal instillation of 65 ZnO or SiO 2 -coated 65 ZnO NPs in rats

From: Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

 

65ZnO

SiO2-coated65ZnO

 

Mean ± SE

Mean ± SE

Lungs

0.28 ± 0.05*

0.14 ± 0.01

Blood

0.79 ± 0.05*

0.61 ± 0.02

Lymph nodes

0.03 ± 0.005

0.12 ± 0.01 #

Bone marrow

2.30 ± 0.12

3.33 ± 0.15 #

Bone

12.40 ± 0.36

13.59 ± 0.52

Skin

4.72 ± 0.60*

3.26 ± 0.13

Brain

0.18 ± 0.02

0.15 ± 0.01

Skeletal muscle

13.27 ± 3.02*

0.66 ± 0.04

Testes

0.49 ± 0.03

0.46 ± 0.03

Kidneys

0.19 ± 0.01

0.17 ± 0.005

Spleen

0.05 ± 0.005

0.04 ± 0.003

Heart

0.07 ± 0.004*

0.06 ± 0.002

Liver

1.32 ± 0.09

1.14 ± 0.02

Stomach

0.20 ± 0.01

0.20 ± 0.01

Small intestine

0.63 ± 0.05

0.55 ± 0.01

Large intestine

0.19 ± 0.02

0.25 ± 0.01 #

Cecum

0.23 ± 0.02

0.24 ± 0.01

Total recovered

88.20 ± 4.36*

72.81 ± 0.53

  1. Data are mean ± SE% instilled dose, n = 5/group.
  2. Total recovered = sum of 65Zn in analyzed organs, feces and urine.
  3. *P < 0.05, ZnO > SiO2-coated ZnO.
  4. # P <0.05, SiO2-coated ZnO > ZnO.