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Figure 3 | Particle and Fibre Toxicology

Figure 3

From: Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

Figure 3

SPIO nanoparticle mass deposited in each region of the lung (top) and regional dosimetry (bottom panel) calculated with the Balb/c specific version of MPPD. Target cell doses are presented in units of mass per surface area of cells for all airways, and as pg/macrophage for the alveolar region only to correspond to experimental in vitro dose-response data. Given a density of 5.2 grams/cm3, a picogram of SPIO particles would contain 154,015 primary 13 nm diameter particles with a surface area of 8.87 × 10−7 cm2.

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