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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

Figure 4

Representative lung histological sections from control and nanoparticle-exposed mice. Examples of H&E stained sections obtained from control (A,C,E) or nanoparticle-exposed mice (B,D,F) at 48 hrs post-inhalation exposure. Arrows highlight the darker brown staining reflecting greatly increased nanoparticle burden observed in alveolar macrophages in treated groups compared to controls. The increase in nanoparticle-laden macrophages observed within the primary bronchus of exposed animals is also highlighted in panel F. (Panels A, B, E and F: 200×; Panels C, D: 400×).

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