Figure 5From: Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routesTranscriptomic analysis of gene regulation by nanoparticles. A) Hierarchical clustering of significantly effected (compared to time matched controls) transcripts shows a higher preponderance of down regulation (green) by SPIO nanoparticle exposures. Up-regulation (red) was more prominent during earlier time points where the most highly induced mRNAs encoded inflammatory cytokines. B) Highest ranking biological processes associated with transcripts up-regulated by in vivo exposure to SPIO nanoparticles. Cellular processes associated with inflammation and clearance of foreign bodies (cytokine production, cell migration, chemotaxis) were significantly upregulated.Back to article page