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Figure 8 | Particle and Fibre Toxicology

Figure 8

From: Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

Figure 8

ISDD simulation of SPIO particle association with C10 epithelial cells in vitro. Modeled and observed SPIO mass doses corresponded well at early time points, but there was evidence at later time points of the involvement of a dose-related process that reduced SPIO nanoparticle doses relative to the predicted amount delivered. Inclusion of a saturable “uptake factor” led to agreement between modeled and observed doses.

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