Skip to main content

Table 1 Summary of microscopic lung lesions

From: Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

Sham control

Time post exposure (hr)

0

6

24

48

96

168

Lung, number examined

5

5

5

5

5

5

Infiltrate Cellular, Macrophage

1a (1.0)b

2 (1.5)

3 (1.3)

1 (1.0)

2 (1.0)

5 (1.0)

Foreign Body (intracellular)

0

0

0

0

0

0

Mixed Inflammation, Interstitium

0

0

0

0

0

1 (1.0)

Nano-particle exposed

 

Lung, number examined

5

5

5

5

5

4

Infiltrate Cellular, Macrophage

5 (1.0)

5 (1.2)

5 (1.0)

5 (2.0)

5 (1.0)

4 (1.0)

Foreign Body (intracellular)

5 (1.0)

5 (1.0)

5 (1.0)

5 (1.0)

5 (1.0)

4 (1.0)

Mixed Inflammation, Interstitium

0

0

0

2 (1.0)

2 (1.0)

1 (1.0)

  1. aNumber diagnosed.
  2. bAverage severity grade in parenthesis (1 = minimal, 2 = mild).