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Table 1 Summary of microscopic lung lesions

From: Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

Sham control Time post exposure (hr)
0 6 24 48 96 168
Lung, number examined 5 5 5 5 5 5
Infiltrate Cellular, Macrophage 1a (1.0)b 2 (1.5) 3 (1.3) 1 (1.0) 2 (1.0) 5 (1.0)
Foreign Body (intracellular) 0 0 0 0 0 0
Mixed Inflammation, Interstitium 0 0 0 0 0 1 (1.0)
Nano-particle exposed  
Lung, number examined 5 5 5 5 5 4
Infiltrate Cellular, Macrophage 5 (1.0) 5 (1.2) 5 (1.0) 5 (2.0) 5 (1.0) 4 (1.0)
Foreign Body (intracellular) 5 (1.0) 5 (1.0) 5 (1.0) 5 (1.0) 5 (1.0) 4 (1.0)
Mixed Inflammation, Interstitium 0 0 0 2 (1.0) 2 (1.0) 1 (1.0)
  1. aNumber diagnosed.
  2. bAverage severity grade in parenthesis (1 = minimal, 2 = mild).