Histopathological observations of mouse
testis following intragastric administration of
NPs for 90 consecutive days.
The blue circle indicates few sperm, breakages or vacuolation,
the yellow circle indicates apoptosis and/or necrosis of Sertoli
cells, and the blue arrow indicates damaged seminiferous tubule.
The red arrows indicate vacuolation, the yellow arrows indicate
irregular arrangement of Sertoli cells, and the red circle
indicates black agglomerates in the testis. The green arrow spot
denotes a representative cell loaded with
TiO2 NPs. The right panel shows the
corresponding Raman spectra identifying specific peaks at about