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Figure 2 | Particle and Fibre Toxicology

Figure 2

From: Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

Figure 2

TEM image of heart in ICR mice after acute exposure to SiNPs. (A) Control group; (B) Numerous free ribosomes, autophagic vacuoles (black arrow), and swollen mitochondria (black arrow) were observed in 177.5 mg/kg SiNPs-treated group; (C) Several autophagic vacuoles (black arrow) were found in pericytes in 177.5 mg/kg SiNPs-treated group; (D) Localization of internalized SiNPs (black arrow) in 177.5 mg/kg SiNPs-treated group. White arrows, denote the original regions which are magnified on the upper corner; Scale bar: (A) 0.5 μm; (B) 2 μm; (C) 0.5 μm; (D) 1 μm. Abbreviation: E, endothelial cell; P, pericyte; L, lumen; Au, autophagic vacuoles; Mi, mitochondria.

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