Figure 7
Effects of SiNPs on autophagy and angiogenesis signaling pathways. (A) Effects of SiNPs on the expression of p-VEGFR2, VEGFR2, p-MEK1/2, MEK1/2, p-Erk1/2, Erk1/2, p-PI3K, PI3K, p-Akt, Akt, p-mTOR, mTOR proteins. GAPDH was used as an internal control to monitor for equal loading. (B) SiNPs induced autophagy through the up-regulation of MAPK/Erk1/2/mTOR signaling and PI3K/Akt/mTOR signaling pathways; while SiNPs inhibited angiogenesis via the down-regulation of VEGFR2/MEK1/2/Erk1/2 and VEGFR2/PI3K/Akt signaling pathways. Data are expressed as means ± S.D. from five independent experiments (*p < 0.05).