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Table 1 Energy metabolism response to intracerebroventricular infusion of infliximab in KKay mice exposed to PM 2.5

From: Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

Phase Measured index Method FA-CON vs PM-CON PM-CON vs PM-Inflix
Estimate SE p-value Estimate SE p-value
Light + Dark O2 Avg −193.125 170.601 0.270 −182.738 170.601 0.296
   RM −171.714 66.509 0.010 −184.556 66.509 0.006
  CO2 Avg −186.684 197.569 0.355 −248.623 197.569 0.222
   RM −159.923 79.478 0.044 −248.577 79.478 0.002
  RER Avg −0.001 0.015 0.969 −0.025 0.015 0.113
   RM 0.001 0.008 0.899 −0.025 0.008 0.003
  Heat Avg −0.020 0.033 0.548 −0.076 0.033 0.030
   RM −0.016 0.012 0.204 −0.078 0.012 0.000
Dark O2 Avg −272.695 195.576 0.178 −186.257 195.576 0.352
   RM −278.074 85.804 0.001 −186.729 85.804 0.030
  CO2 Avg −273.400 234.828 0.257 −289.425 234.828 0.231
   RM −280.245 106.432 0.009 −287.488 106.432 0.007
  RER Avg −0.002 0.019 0.901 −0.037 0.019 0.062
   RM −0.003 0.010 0.753 −0.036 0.010 0.000
  Heat Avg −0.035 0.035 0.338 −0.079 0.035 0.036
   RM −0.036 0.016 0.022 −0.079 0.016 0.000
  1. O2 consumption, CO2 production, RER and heat production of mice measured by indirect calorimetry over a 24 hrs period (from 10:00 am to 10:00 am the next day) after 5-week PM2.5 exposure. n = 6.
  2. Avg = analysis performed based on mice averages over cycles. Covariates in the model include PM exposure, treatment group, and the interaction between PM and treatment group.
  3. RM = analysis with repeated measurements. The correlation structure within mice was assumed to be autoregressive-1. Covariates in the model include PM, treatment group, PM x treatment interaction, and time.
  4. Mean model using averages over cycles (Avg): E (Y) = b0 + b1PM + b2 Trt + b3 PM*Trt.
  5. Mean model using repeated measures data (RM): E (Y + b1P) = b0 M + b2 Trt + b3 PM*Trt + b4cycle.
  6. Covariance structure: autoregressive-1.