From: Biokinetics and effects of barium sulfate nanoparticles
Route (dose) | IT Instillation (1 mg/kg) | Gavage (5 mg/kg) | IV Injection (1 mg/kg) |
---|---|---|---|
 | ng/g ± SE | ng/g ± SE | ng/g ± SE |
Lungs | 69074.5 ± 4993.8 | < 0.01 | 9847.5 ± 983.8 |
Bone | 2271.9 ± 124.6* | 0.079 ± 0.014 | 3788.5 ± 156.6# |
Bone marrow | 1018.3 ± 71.4* | 0.13 ± 0.12 | 1641.3 ± 62.2# |
Cecum | 119.3 ± 23.8 | < 0.01 | 61.2 ± 4.2# |
TB LN | 113.1 ± 16.3 | < 0.01 | 64.8 ± 14.1 |
Large Intestine | 106.6 ± 31.2 | < 0.01 | 72.8 ± 6.1# |
Small Intestine | 43.2 ± 6.7 | < 0.01 | 28.5 ± 2.3 |
Spleen | 37.5 ± 1.5 | < 0.01 | 3256.4 ± 391.2# |
Stomach | 30.3 ± 18.6* | 0.016 ± 0.016 | 46.3 ± 10.1 |
Kidneys | 7.8 ± 2.7 | < 0.01 | 140.8 ± 12.9# |
Plasma | 3.6 ± 1.2 | < 0.01 | 0.1 ± 0.1 |
Heart | 3.6 ± 1.2 | < 0.01 | 77.5 ± 10.8# |
Brain | 3.5 ± 0.8 | < 0.01 | 18.6 ± 4.5# |
RBC | 3.1 ± 0.5 | < 0.01 | < 0.01 |
Skeletal Muscle | 3.0 ± 0.8 | < 0.01 | 8.3 ± 0.5# |
Liver | 2.5 ± 0.5 | < 0.01 | 1760.0 ± 221.9# |
Skin | 2.5 ± 1.0 | < 0.01 | 2.5 ± 0.8 |
Testes | 0.7 ± 0.7 | < 0.01 | 3.3 ± 3.3 |