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Table 6 Comparison of tissue barium concentrations at 7 days after dosing

From: Biokinetics and effects of barium sulfate nanoparticles

Route (dose) IT Instillation (1 mg/kg) Gavage (5 mg/kg) IV Injection (1 mg/kg)
  ng/g ± SE ng/g ± SE ng/g ± SE
Lungs 69074.5 ± 4993.8 < 0.01 9847.5 ± 983.8
Bone 2271.9 ± 124.6* 0.079 ± 0.014 3788.5 ± 156.6#
Bone marrow 1018.3 ± 71.4* 0.13 ± 0.12 1641.3 ± 62.2#
Cecum 119.3 ± 23.8 < 0.01 61.2 ± 4.2#
TB LN 113.1 ± 16.3 < 0.01 64.8 ± 14.1
Large Intestine 106.6 ± 31.2 < 0.01 72.8 ± 6.1#
Small Intestine 43.2 ± 6.7 < 0.01 28.5 ± 2.3
Spleen 37.5 ± 1.5 < 0.01 3256.4 ± 391.2#
Stomach 30.3 ± 18.6* 0.016 ± 0.016 46.3 ± 10.1
Kidneys 7.8 ± 2.7 < 0.01 140.8 ± 12.9#
Plasma 3.6 ± 1.2 < 0.01 0.1 ± 0.1
Heart 3.6 ± 1.2 < 0.01 77.5 ± 10.8#
Brain 3.5 ± 0.8 < 0.01 18.6 ± 4.5#
RBC 3.1 ± 0.5 < 0.01 < 0.01
Skeletal Muscle 3.0 ± 0.8 < 0.01 8.3 ± 0.5#
Liver 2.5 ± 0.5 < 0.01 1760.0 ± 221.9#
Skin 2.5 ± 1.0 < 0.01 2.5 ± 0.8
Testes 0.7 ± 0.7 < 0.01 3.3 ± 3.3
  1. Data are mean ± SE, n = 5/group.
  2. *P <0.05, IT instillation higher than gavage. All other tissues post-gavage were lower than detection limit ~0.01 ng/g Barium.
  3. #P <0.05, IV injection higher than IT instillation.
  4. TB LN, tracheobronchial lymph nodes.