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Table 6 Comparison of tissue barium concentrations at 7 days after dosing

From: Biokinetics and effects of barium sulfate nanoparticles

Route (dose)

IT Instillation (1 mg/kg)

Gavage (5 mg/kg)

IV Injection (1 mg/kg)

 

ng/g ± SE

ng/g ± SE

ng/g ± SE

Lungs

69074.5 ± 4993.8

< 0.01

9847.5 ± 983.8

Bone

2271.9 ± 124.6*

0.079 ± 0.014

3788.5 ± 156.6#

Bone marrow

1018.3 ± 71.4*

0.13 ± 0.12

1641.3 ± 62.2#

Cecum

119.3 ± 23.8

< 0.01

61.2 ± 4.2#

TB LN

113.1 ± 16.3

< 0.01

64.8 ± 14.1

Large Intestine

106.6 ± 31.2

< 0.01

72.8 ± 6.1#

Small Intestine

43.2 ± 6.7

< 0.01

28.5 ± 2.3

Spleen

37.5 ± 1.5

< 0.01

3256.4 ± 391.2#

Stomach

30.3 ± 18.6*

0.016 ± 0.016

46.3 ± 10.1

Kidneys

7.8 ± 2.7

< 0.01

140.8 ± 12.9#

Plasma

3.6 ± 1.2

< 0.01

0.1 ± 0.1

Heart

3.6 ± 1.2

< 0.01

77.5 ± 10.8#

Brain

3.5 ± 0.8

< 0.01

18.6 ± 4.5#

RBC

3.1 ± 0.5

< 0.01

< 0.01

Skeletal Muscle

3.0 ± 0.8

< 0.01

8.3 ± 0.5#

Liver

2.5 ± 0.5

< 0.01

1760.0 ± 221.9#

Skin

2.5 ± 1.0

< 0.01

2.5 ± 0.8

Testes

0.7 ± 0.7

< 0.01

3.3 ± 3.3

  1. Data are mean ± SE, n = 5/group.
  2. *P <0.05, IT instillation higher than gavage. All other tissues post-gavage were lower than detection limit ~0.01 ng/g Barium.
  3. #P <0.05, IV injection higher than IT instillation.
  4. TB LN, tracheobronchial lymph nodes.